{"id":"W4404171033","doi":"10.1101/2024.11.06.622394","title":"Uttroside B, a US-FDA-Designated Orphan Drug Against Hepatocellular Carcinoma (HCC), Impedes Non-alcoholic Steatohepatitis (NASH) and NASH -Induced HCC","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"","keywords":"Steatohepatitis; Hepatocellular carcinoma; Medicine; Drug; Nonalcoholic steatohepatitis; Fatty liver; Internal medicine; Pharmacology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001069482,0.0003613411,0.0002521829,0.0004359751,0.0001555507,0.0001718595,0.0001732394,0.0002610713,0.002476993],"category_scores_gemma":[0.00006403252,0.00009505492,0.0002591674,0.0002406018,0.0002290426,0.0002122311,0.0002013496,0.0004718888,0.0003751967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078616,"about_ca_system_score_gemma":0.0002646223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002752476,"about_ca_topic_score_gemma":0.0006143018,"domain_scores_codex":[0.9999311,0.00001391622,0.000007875265,0.00001208643,0.0000184545,0.0000165052],"domain_scores_gemma":[0.9999338,0.000006324954,0.0000204925,0.000006841411,0.000009878651,0.00002260659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003747223,0.0001032669,0.0003739367,0.0002299636,0.00001461887,0.0001210097,0.000009526574,0.00007778734,0.9895482,0.0002242972,0.0001599178,0.00876271],"study_design_scores_gemma":[0.0001345716,0.00272272,0.009562657,0.00005623668,0.00007130059,0.001122815,0.0000615978,0.001044044,0.9723986,0.0001825244,0.01262936,0.00001347967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597163,0.0199629,0.006869524,0.0004841893,0.0002293049,0.0001411969,0.001156728,0.0003126906,0.01112721],"genre_scores_gemma":[0.9774737,0.01064586,0.005600267,0.0002448086,0.00004804487,0.00009979966,0.0008254236,0.00002167159,0.005040478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002476993,"threshold_uncertainty_score":0.008286357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370238022559592,"score_gpt":0.2242252168905028,"score_spread":0.2105228366649068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}