{"id":"W4404171714","doi":"10.1101/2024.11.06.622320","title":"Topoisomerase IIb binding underlies frequently mutated elements in cancer genomes","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; SickKids Foundation; University of Toronto; Ontario Institute for Cancer Research; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Hospital for Sick Children","funders":"","keywords":"Topoisomerase; Genome; Genetics; Cancer; Biology; DNA; Computational biology; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213506,0.0002701972,0.0001968197,0.0004808719,0.0002083182,0.000396011,0.0001558148,0.0003043135,0.004065474],"category_scores_gemma":[0.0002058729,0.0001985629,0.0001390493,0.0003183702,0.0001592745,0.0001178416,0.0002470149,0.0002869982,0.0007622191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002994328,"about_ca_system_score_gemma":0.0001148153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008890934,"about_ca_topic_score_gemma":0.001187994,"domain_scores_codex":[0.999886,0.00001394759,0.00000398555,0.00003282903,0.00003503772,0.00002818076],"domain_scores_gemma":[0.999923,0.00001213167,0.00002003555,0.00001044167,0.00001032553,0.00002405573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001872374,0.00001670891,0.006393733,0.00006034803,0.00002425846,0.0001877069,0.0000329894,0.0004589333,0.9887214,0.0004712004,0.0005196412,0.002925751],"study_design_scores_gemma":[0.00002888308,0.0001377797,0.1246824,0.00001417556,0.00004958938,0.001600899,0.0001496829,0.007347378,0.8566351,0.0008947692,0.008447466,0.00001170726],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912771,0.0008958901,0.003818107,0.0001360759,0.0000242832,0.000007869421,0.001016487,0.0002685693,0.0025558],"genre_scores_gemma":[0.9943674,0.0002274122,0.001767495,0.00002721063,0.000008180326,0.000006132931,0.001323156,0.0000477311,0.002225306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004065474,"threshold_uncertainty_score":0.01360041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813890957938667,"score_gpt":0.2624782244833876,"score_spread":0.2443393149040009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}