{"id":"W4404176808","doi":"10.1101/2024.11.05.622109","title":"SysQuan: repurposing SILAC mice for the affordable absolute quantitation of the human proteome","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Advanced Proteomics Techniques and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Jewish General Hospital; Research Manitoba","funders":"","keywords":"Stable isotope labeling by amino acids in cell culture; Repurposing; Proteome; Absolute (philosophy); Computational biology; Chemistry; Proteomics; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00213353,0.001739638,0.0007672324,0.002679158,0.0009949636,0.001640392,0.002155536,0.001423837,0.06162754],"category_scores_gemma":[0.001205357,0.001405317,0.0008087484,0.0006888073,0.0008725579,0.001222758,0.001569363,0.00333909,0.01706561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000781959,"about_ca_system_score_gemma":0.0008602828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008870959,"about_ca_topic_score_gemma":0.002276713,"domain_scores_codex":[0.9987248,0.0002209323,0.0001047823,0.0002830357,0.000546824,0.0001197101],"domain_scores_gemma":[0.9992462,0.0001760824,0.0001213873,0.0002175399,0.0001467482,0.00009200843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000913962,0.0001607266,0.0009196399,0.0009089577,0.0001012619,0.0003787499,0.0002119367,0.001098048,0.8220601,0.01101969,0.1120205,0.05020639],"study_design_scores_gemma":[0.0002747778,0.0003145481,0.003287141,0.0001910396,0.00005961489,0.001018954,0.00004253063,0.01938978,0.7518542,0.002914876,0.2205567,0.00009569857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03583484,0.002390065,0.8011099,0.003576558,0.002204828,0.001299421,0.04596596,0.08516191,0.02245645],"genre_scores_gemma":[0.1493654,0.002505154,0.7347136,0.003630545,0.0004324485,0.005594834,0.0383141,0.009398957,0.05604501],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.06162754,"threshold_uncertainty_score":0.2061647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017700878058946,"score_gpt":0.268698311942232,"score_spread":0.2485213031616425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}