{"id":"W4404186521","doi":"10.1038/s41409-024-02464-3","title":"Fedratinib as an alternative to splenectomy for refractory splenomegaly prior to transplant for myelofibrosis","year":2024,"lang":"en","type":"letter","venue":"Bone Marrow Transplantation","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's College Hospital; Princess Margaret Cancer Centre; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Myelofibrosis; Splenectomy; Refractory (planetary science); Surgery; Internal medicine; Spleen; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004266426,0.0003662966,0.0005774733,0.0004571656,0.001287546,0.001373981,0.0007433472,0.008158591,0.003980279],"category_scores_gemma":[0.002809175,0.0002416121,0.0009247542,0.0003431047,0.0006750592,0.0008870499,0.0004730706,0.007292094,0.001468255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002187086,"about_ca_system_score_gemma":0.001472905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001633475,"about_ca_topic_score_gemma":0.006728099,"domain_scores_codex":[0.9996909,0.00008073906,0.00004530511,0.00003035515,0.00006559415,0.00008720996],"domain_scores_gemma":[0.9992181,0.0003145161,0.00008629074,0.00002500369,0.00004720241,0.0003089082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"case_report","study_design_scores_codex":[0.002951928,0.0008162092,0.01362329,0.000448453,0.0002135783,0.2562724,0.0002973024,0.00348383,0.006067812,0.0130024,0.5304945,0.1723284],"study_design_scores_gemma":[0.002306504,0.002083704,0.01771052,0.0009789033,0.0002672626,0.3319777,0.0004659414,0.005952279,0.003574352,0.02179965,0.6127326,0.0001506584],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.06814498,0.02211771,0.001886284,0.8161139,0.02365622,0.0001294651,0.0004621183,0.0002231013,0.06726614],"genre_scores_gemma":[0.4642413,0.01415833,0.003885927,0.4218785,0.06710934,0.0001311851,0.0005066167,0.0001021355,0.02798666],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008158591,"threshold_uncertainty_score":0.01586848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02804379887307443,"score_gpt":0.3129004296434697,"score_spread":0.2848566307703952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}