{"id":"W4404204894","doi":"10.1101/2024.11.07.622474","title":"Genetic Basis, Quantitative Nature, and Functional Relevance of Evolutionarily Conserved DNA Methylation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; BC Children's Hospital; Genome British Columbia; University of British Columbia","funders":"","keywords":"Biology; DNA methylation; Relevance (law); Evolutionary biology; Genetics; Computational biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003779547,0.0001379137,0.0001873206,0.0005959714,0.0002017948,0.000379829,0.0001993228,0.0002524107,0.001880686],"category_scores_gemma":[0.0007239163,0.0001209948,0.0001543604,0.0006630857,0.0003603852,0.0001451404,0.0005889662,0.0003222669,0.0002067313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001572516,"about_ca_system_score_gemma":0.00009229105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366402,"about_ca_topic_score_gemma":0.001347822,"domain_scores_codex":[0.9997478,0.00004677267,0.0000128476,0.0001312142,0.00003531664,0.00002601827],"domain_scores_gemma":[0.9996474,0.0001436813,0.0000707319,0.00005959332,0.00004126267,0.00003737126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005193009,0.00002067858,0.1679041,0.0001961405,0.0002601017,0.0003149164,0.0004520796,0.0008947196,0.7984572,0.001185536,0.0002643913,0.02953084],"study_design_scores_gemma":[0.00001387391,0.00008799006,0.935937,0.00001576233,0.00009258907,0.000940915,0.0002345869,0.003528828,0.05460886,0.001313782,0.003209239,0.00001641624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949699,0.0005973307,0.002823725,0.00005391057,0.000003814112,0.000004003225,0.0007377305,0.00002800281,0.0007816473],"genre_scores_gemma":[0.997773,0.0001460232,0.00103809,0.00002957257,0.000005074812,0.00000501401,0.0005046353,0.00001110288,0.0004873976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001880686,"threshold_uncertainty_score":0.006291509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467820666551971,"score_gpt":0.2445806412304619,"score_spread":0.2299024345649422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}