{"id":"W4404205128","doi":"10.1016/j.nucmedbio.2024.108970","title":"Convection-enhanced delivery of [177Lu]Lu-labeled gold nanoparticles combined with anti-PD1 checkpoint immunotherapy improves the survival of immunocompetent C57BL/6J mice with orthotopic GL261 murine glioma tumors","year":2024,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University Health Network; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Glioma; Immunotherapy; Medicine; Cancer research; Cancer immunotherapy; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484954,0.0004705189,0.0004337049,0.0001848471,0.00009247244,0.0001925803,0.0001912312,0.0003787247,0.0005287547],"category_scores_gemma":[0.00006073411,0.0001448303,0.0002757522,0.00009216318,0.0002174797,0.0002467878,0.0001047596,0.0005914625,0.0001870782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000240871,"about_ca_system_score_gemma":0.0001717809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006541537,"about_ca_topic_score_gemma":0.0007536501,"domain_scores_codex":[0.999903,0.00001131403,0.000005499455,0.00002775936,0.00001946844,0.00003302043],"domain_scores_gemma":[0.9999478,0.000006034373,0.00001708405,0.000003838623,0.000006251675,0.00001904027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001658335,0.00004761941,0.00003671999,0.00001526753,0.000002079677,0.00001131717,0.000006729322,0.00005470558,0.9991912,0.00001337051,0.00002116689,0.0004341652],"study_design_scores_gemma":[0.00003258689,0.001410404,0.001118516,0.000002260644,0.00001457354,0.00005842789,0.00001007404,0.0008670309,0.995915,0.00001175657,0.0005554878,0.000003911701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974083,0.0007192408,0.001178979,0.00006935832,0.0000262841,0.00001969578,0.0001244012,0.00006452328,0.0003891014],"genre_scores_gemma":[0.9940853,0.0006910071,0.002464453,0.0000633113,0.00001767005,0.00005139256,0.0002206263,0.00002232301,0.002383915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006541537,"threshold_uncertainty_score":0.001768827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448298979736361,"score_gpt":0.2505301038137264,"score_spread":0.2360471140163628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}