{"id":"W4404208635","doi":"10.1111/fcp.13043","title":"The synergy between alkylating agents and ERCC1–XPF inhibitors is p53 dependent","year":2024,"lang":"en","type":"article","venue":"Fundamental and Clinical Pharmacology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Institute of Canada; University of Ottawa; Northern Alberta Institute of Technology; University of Alberta","funders":"Olav Raagholt og Gerd Meidel Raagholts stiftelse","keywords":"ERCC1; Biology; Chemistry; DNA damage; Genetics; DNA; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000491753,0.0001594556,0.0001713013,0.00001982841,0.0002053512,0.00007375261,0.0001293124,0.0001903335,0.00008998426],"category_scores_gemma":[0.00003279115,0.0001172273,0.0001040877,0.00004453627,0.0002538174,0.000006493012,0.0004378873,0.0002354976,0.00002493709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001393416,"about_ca_system_score_gemma":0.0000363675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001505116,"about_ca_topic_score_gemma":0.00001216857,"domain_scores_codex":[0.9985748,0.0001561709,0.0003861152,0.0004924313,0.0001113243,0.0002791852],"domain_scores_gemma":[0.9994418,0.0001969512,0.00005852159,0.0001153036,0.00001636294,0.0001710843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003816409,0.0002800443,0.0995773,0.0001287107,0.002373876,0.0001345087,0.0002447609,0.000002812405,0.4340686,0.0003802759,0.1134302,0.3489973],"study_design_scores_gemma":[0.002317028,0.002178459,0.01595354,0.0000526545,0.0005689005,0.00009385144,0.000432832,0.0009812422,0.1923567,0.00133238,0.7831279,0.0006045303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926895,0.003173632,0.00003494291,0.001445199,0.001894865,0.000185791,0.00003617947,0.00002968627,0.0005102059],"genre_scores_gemma":[0.9932645,0.00190502,0.00006860065,0.002059026,0.001229087,0.00002116829,0.00002818867,0.00002196078,0.001402453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6696978,"threshold_uncertainty_score":0.4780392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0279155286440905,"score_gpt":0.369835457807744,"score_spread":0.3419199291636534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}