{"id":"W4404214653","doi":"10.14802/jmd.24182","title":"Brittle Response to Levodopa as a Marker of Parkinson’s Disease Phenotype Characterized by Heavy Motor and Non Motor Burden","year":2024,"lang":"en","type":"article","venue":"Journal of Movement Disorders","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ontario Brain Institute; Toronto Western Hospital","funders":"","keywords":"Medicine; Disease; Parkinson's disease; Phenotype; Levodopa; Physical medicine and rehabilitation; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004047727,0.0006377341,0.0005147802,0.001442953,0.0003589569,0.0006482364,0.0004411978,0.0006940045,0.002357645],"category_scores_gemma":[0.001549889,0.0001890444,0.0004305889,0.0006569817,0.0004943176,0.0004033733,0.0006102058,0.000636469,0.0002983672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002911157,"about_ca_system_score_gemma":0.0001882329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222302,"about_ca_topic_score_gemma":0.001648777,"domain_scores_codex":[0.9996639,0.00006110653,0.00004704569,0.00005873773,0.000100825,0.00006832866],"domain_scores_gemma":[0.9982437,0.0002766826,0.0008379448,0.00007878461,0.0001813167,0.0003815267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006215319,0.0002829773,0.8602917,0.0001661488,0.0003717846,0.01367124,0.0003836574,0.0004871039,0.1078744,0.0001932051,0.0004700918,0.009592437],"study_design_scores_gemma":[0.00003144353,0.0009727246,0.9821689,0.00001520225,0.00007911593,0.01170662,0.0002105194,0.0007378547,0.003504336,0.0001839397,0.00037125,0.00001815586],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972733,0.0003995123,0.0002163013,0.00005995248,0.00001838075,0.00001968735,0.0002511926,0.00002749307,0.001734204],"genre_scores_gemma":[0.9991836,0.00006838766,0.0001481957,0.00003460711,0.000009498928,0.000006602067,0.000205901,0.000006648811,0.000336446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002357645,"threshold_uncertainty_score":0.007887065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008145521297880027,"score_gpt":0.2561764867180136,"score_spread":0.2480309654201336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}