{"id":"W4404224827","doi":"10.1038/s41594-024-01414-3","title":"Structural basis of the mechanism and inhibition of a human ceramide synthase","year":2024,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Ontario Ministry of Economic Development and Innovation; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; Ministero dello Sviluppo Economico; McGill University; Diamond Light Source; Genome Canada; Wellcome Trust; European Commission; Pfizer","keywords":"Ceramide; Mechanism (biology); ATP synthase; Ceramide synthase; Chemistry; Cell biology; Sphingolipid; Biochemistry; Biology; Enzyme; Apoptosis; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246386,0.0002009375,0.0002483167,0.00007833038,0.00007983932,0.00001577934,0.0001836703,0.000482256,0.00002014105],"category_scores_gemma":[0.0001053269,0.000134359,0.000181346,0.0001617669,0.0002423676,0.000005469649,0.0001874892,0.0003196575,1.781707e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000751047,"about_ca_system_score_gemma":0.00004511429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004167132,"about_ca_topic_score_gemma":0.00001118225,"domain_scores_codex":[0.9988877,0.0001270474,0.000278537,0.0003853176,0.0001167684,0.0002046599],"domain_scores_gemma":[0.9994338,0.0000136313,0.0001112913,0.0003058427,0.00008919188,0.00004631265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002417436,0.000001907744,0.0002279911,0.00006760582,0.0000769086,0.000003277796,0.00004714563,0.000007012713,0.9299601,0.06872055,0.00001993265,0.0008434037],"study_design_scores_gemma":[0.0002801397,0.0001165101,0.001744487,0.00004473843,0.00006794824,0.00004995701,0.00002807939,0.0001123188,0.9770293,0.02022474,0.0001563391,0.0001454564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913172,0.007288882,0.0002881006,0.0001831788,0.0005630359,0.0001814885,0.0001050786,0.00001271082,0.00006036432],"genre_scores_gemma":[0.9990379,0.00003527301,0.0003755821,0.0002248447,0.000172878,0.000004965058,0.000106817,0.00002124717,0.00002050214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04849581,"threshold_uncertainty_score":0.5479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004387532457185195,"score_gpt":0.2758021883363815,"score_spread":0.2714146558791963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}