{"id":"W4404225574","doi":"10.1021/acscatal.4c05759","title":"Asymmetric Csp <sup>3</sup> –Csp <sup>3</sup> Bond Formation via Ni-Catalyzed Regio- and Enantioselective Hydroalkylation of Linear 1,3-Diene through Carbonyl Umpolung","year":2024,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis","funders":"Centre in Green Chemistry and Catalysis; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Canada Research Chairs; McGill University","keywords":"Enantioselective synthesis; Umpolung; Catalysis; Chemistry; Diene; Organic chemistry; Medicinal chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008420664,0.0003614908,0.000161902,0.00008714452,0.0001688231,0.0001712274,0.0003310933,0.0001879414,0.002327751],"category_scores_gemma":[0.0001288468,0.0001340277,0.0002059359,0.0001308359,0.0002074075,0.0003789867,0.0003853244,0.0005057864,0.0006803374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321286,"about_ca_system_score_gemma":0.0002879896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005763724,"about_ca_topic_score_gemma":0.001473027,"domain_scores_codex":[0.9999385,0.000005828132,0.000003577227,0.000009902212,0.0000199516,0.00002234925],"domain_scores_gemma":[0.9999663,0.000005466185,0.000009794338,0.000006513239,0.00000560207,0.000006388248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001759574,0.00005339149,0.0004049783,0.0003735799,0.00002534049,0.0005645106,0.0001346584,0.00166349,0.9626661,0.00956523,0.001702105,0.02267075],"study_design_scores_gemma":[0.000009276524,0.0000933691,0.0004402348,0.0000049767,0.000005951817,0.0001654346,0.00002319212,0.002881592,0.9899917,0.0004744017,0.005899562,0.00001031993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359843,0.001402199,0.02680769,0.0003788152,0.0001196081,0.00008238333,0.0006709535,0.0004824981,0.03407149],"genre_scores_gemma":[0.9904447,0.0009977944,0.005627089,0.00005426515,0.00001204777,0.0000263045,0.0002751224,0.00004043619,0.002522235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002327751,"threshold_uncertainty_score":0.007787049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042886074953877,"score_gpt":0.2399392977732318,"score_spread":0.229510437023693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}