{"id":"W4404225574","doi":"10.1021/acscatal.4c05759","title":"Asymmetric Csp <sup>3</sup> –Csp <sup>3</sup> Bond Formation via Ni-Catalyzed Regio- and Enantioselective Hydroalkylation of Linear 1,3-Diene through Carbonyl Umpolung","year":2024,"lang":"en","type":"article","venue":"ACS Catalysis","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre in Green Chemistry and Catalysis","funders":"Centre in Green Chemistry and Catalysis; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Canada Research Chairs; McGill University","keywords":"Enantioselective synthesis; Umpolung; Catalysis; Chemistry; Diene; Organic chemistry; Medicinal chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007040125,0.0006743885,0.001002377,0.001650838,0.0003917889,0.0001890284,0.0005287329,0.0005424442,0.0001919566],"category_scores_gemma":[0.0006207809,0.0006619788,0.0005414117,0.007219261,0.0002264475,0.00170439,0.0002727204,0.000559566,0.0001343234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004941028,"about_ca_system_score_gemma":0.0001556668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001466679,"about_ca_topic_score_gemma":0.00004013978,"domain_scores_codex":[0.9954451,0.00009291327,0.001386974,0.001176072,0.001173012,0.0007258788],"domain_scores_gemma":[0.9971306,0.0004908319,0.0005715029,0.001103681,0.0004532202,0.0002501297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001083668,0.002914603,0.01011796,0.008483707,0.01952936,0.0003961037,0.09487031,0.04575868,0.2073423,0.004438699,0.01970032,0.5853643],"study_design_scores_gemma":[0.001511312,0.00007386073,0.0001505592,0.0001872222,0.002432474,0.0001261015,0.002621465,0.4620038,0.517911,0.0007092146,0.01120919,0.001063865],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.957685,0.01179112,0.01255234,0.0005559783,0.00009713873,0.0004852762,0.0002917699,0.0005669105,0.01597448],"genre_scores_gemma":[0.992569,0.0009902047,0.0007760638,0.00009284279,0.0003112818,0.0001028471,0.003442139,0.0001192392,0.001596409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5843005,"threshold_uncertainty_score":0.9995831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042886074953877,"score_gpt":0.2399392977732318,"score_spread":0.229510437023693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}