{"id":"W4404228528","doi":"10.1128/msystems.01004-24","title":"A comprehensive two-hybrid analysis to explore the <i>Legionella pneumophila</i> effector–effector interactome","year":2024,"lang":"en","type":"article","venue":"mSystems","topic":"Legionella and Acanthamoeba research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds Léon Fredericq; Wallonie-Bruxelles International; Université de Liège; Fonds De La Recherche Scientifique - FNRS","keywords":"Effector; Interactome; Legionella pneumophila; Legionella; Biology; Cell biology; Genetics; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003017325,0.0002695748,0.000332568,0.0002193516,0.0001437955,0.0002529846,0.0004594789,0.00007682063,0.00001493167],"category_scores_gemma":[0.00004026973,0.0001762241,0.0004009388,0.0007915283,0.00007537838,0.000005995236,0.0002657826,0.0002239827,0.0006148544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004395431,"about_ca_system_score_gemma":0.00006059689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002518322,"about_ca_topic_score_gemma":0.00004230137,"domain_scores_codex":[0.9980302,0.0002817905,0.0002789399,0.0006354685,0.000342352,0.0004312028],"domain_scores_gemma":[0.9987852,0.000155543,0.00004103079,0.0007077948,0.0001134306,0.0001970041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001109365,0.00004079036,0.001594621,0.0002371578,0.00154186,0.0001447312,0.0004661123,0.0007713143,0.9486251,0.0000358986,0.04560817,0.0008233024],"study_design_scores_gemma":[0.0004864579,0.000474483,0.001179685,0.0001725288,0.0003459723,0.0001505985,0.0003980229,0.003487699,0.1564352,0.00001365101,0.8363229,0.0005327876],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920138,0.00325295,0.001111127,0.001056363,0.000995476,0.0007080858,0.00007059484,0.00006391262,0.0007277271],"genre_scores_gemma":[0.9964077,0.00008169295,0.00001103264,0.0005551064,0.001225787,0.0002126597,0.0002217432,0.00004644831,0.001237763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7921899,"threshold_uncertainty_score":0.7902914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02807931360018389,"score_gpt":0.3156697454632214,"score_spread":0.2875904318630375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}