{"id":"W4404230706","doi":"10.1093/neuonc/noae165.0967","title":"EXTH-36. SHIFTING FROM EPIGENETICS TO THE EPICHAPEROME: HSP90 AS A THERAPEUTIC TARGET FOR H3K27M DIFFUSE MIDLINE GLIOMA (DMG)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation","funders":"","keywords":"Epigenetics; Hsp90; Glioma; Medicine; Cancer research; Biology; Heat shock protein; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007778894,0.0002980298,0.0002449142,0.0001433401,0.00009713856,0.0001861791,0.0001523453,0.0001790339,0.001377769],"category_scores_gemma":[0.00004439743,0.00009164637,0.0001587105,0.0001743713,0.0001700452,0.000115068,0.00013991,0.0004176981,0.0004091532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002355631,"about_ca_system_score_gemma":0.0001425734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004513364,"about_ca_topic_score_gemma":0.001106428,"domain_scores_codex":[0.9999365,0.00000601317,0.000004240262,0.00001424503,0.00002098188,0.00001803775],"domain_scores_gemma":[0.9999728,0.000002550647,0.000007534794,0.000003287711,0.000003178891,0.00001065712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001546892,0.00003218831,0.0001453833,0.00004401756,0.000006986596,0.00005639787,0.000009342431,0.000123138,0.9962686,0.00008567453,0.0001348459,0.002938785],"study_design_scores_gemma":[0.00003631182,0.0004860088,0.003113395,0.000003592321,0.00001207104,0.0002086101,0.00001157348,0.0003861352,0.9926673,0.0000391008,0.003031776,0.000004207032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910395,0.002187962,0.00262607,0.0002204219,0.00002972466,0.00007162478,0.001646408,0.000170692,0.002007568],"genre_scores_gemma":[0.992462,0.001150506,0.00233972,0.0001368822,0.000006176765,0.00003043446,0.001228964,0.00002256513,0.002622807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377769,"threshold_uncertainty_score":0.004609048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02822209775957269,"score_gpt":0.3418564886060926,"score_spread":0.3136343908465199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}