{"id":"W4404230715","doi":"10.1093/neuonc/noae165.0531","title":"DDDR-46. TARGETING TRANSGLUTAMINASE 2 (TGM2) ENHANCES SENSITIVITY OF GLIOBLASTOMA CELL LINES TO RADIOTHERAPY AND TEMOZOLOMIDE","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Blood properties and coagulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Temozolomide; Glioblastoma; Tissue transglutaminase; Radiation therapy; Sensitivity (control systems); Cancer research; Medicine; Chemistry; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003368463,0.0001486889,0.0004056115,0.0001243568,0.00004768644,0.00001433953,0.00003562666,0.0001334076,0.0000561898],"category_scores_gemma":[0.00008294455,0.0001198655,0.00007178306,0.0002022629,0.00008774539,0.00006609497,0.00002348092,0.0001969742,0.00001225226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004503221,"about_ca_system_score_gemma":0.0001177932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000597353,"about_ca_topic_score_gemma":0.00006053457,"domain_scores_codex":[0.9988552,0.0001855906,0.0002916875,0.0003296887,0.0001263703,0.0002115101],"domain_scores_gemma":[0.9992377,0.0003993672,0.00005245311,0.0001308538,0.00006365943,0.0001159971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006415242,0.00009756067,0.0003361653,0.0002472257,0.00002578542,0.00023405,0.001333426,0.0000390669,0.8883307,0.00001592775,0.0007684001,0.1079302],"study_design_scores_gemma":[0.0008565016,0.003899442,0.0008485793,0.00008641414,0.0001119181,0.0002628201,0.0002646077,0.006171804,0.8977773,0.00001573274,0.08957472,0.0001301852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894543,0.002943812,0.0009247051,0.00534022,0.0004440649,0.0003663098,0.000006016994,0.00008500319,0.0004355345],"genre_scores_gemma":[0.996211,0.0004420805,0.001425024,0.001360188,0.000394615,0.00001510634,0.000003170453,0.00002966901,0.0001191296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1078,"threshold_uncertainty_score":0.4887973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276079973339035,"score_gpt":0.2786474382970565,"score_spread":0.2658866385636661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}