{"id":"W4404230715","doi":"10.1093/neuonc/noae165.0531","title":"DDDR-46. TARGETING TRANSGLUTAMINASE 2 (TGM2) ENHANCES SENSITIVITY OF GLIOBLASTOMA CELL LINES TO RADIOTHERAPY AND TEMOZOLOMIDE","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Blood properties and coagulation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Temozolomide; Glioblastoma; Tissue transglutaminase; Radiation therapy; Sensitivity (control systems); Cancer research; Medicine; Chemistry; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032615,0.0003389279,0.0004130121,0.0001750508,0.0001250173,0.0002685796,0.0001774698,0.0002849618,0.001423965],"category_scores_gemma":[0.0000618405,0.0001232583,0.000242206,0.0001964147,0.0001656046,0.0001529772,0.0001446235,0.0005889188,0.0005195259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342683,"about_ca_system_score_gemma":0.0001705939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009732349,"about_ca_topic_score_gemma":0.001293755,"domain_scores_codex":[0.9998641,0.00001793331,0.00001813539,0.00003448787,0.00003657265,0.00002870647],"domain_scores_gemma":[0.999956,0.000004001166,0.00001207019,0.000007651569,0.000005673629,0.00001453803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021513,0.00006169893,0.0001189821,0.00003512651,0.000005286842,0.00001823384,0.000009038172,0.00008911734,0.9982089,0.00004015198,0.0001091513,0.001202257],"study_design_scores_gemma":[0.00001800849,0.0005294993,0.00162622,0.000003230974,0.00001162413,0.00009614639,0.00001204487,0.00059221,0.9949943,0.00001327181,0.002099959,0.000003447735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920672,0.002109356,0.002250161,0.0001691806,0.00008400843,0.00004548603,0.001025143,0.000303153,0.001946319],"genre_scores_gemma":[0.9935535,0.0007966955,0.001677644,0.0000732891,0.000007052,0.00004353613,0.001330802,0.00002294018,0.00249445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001423965,"threshold_uncertainty_score":0.004763603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01276079973339035,"score_gpt":0.2786474382970565,"score_spread":0.2658866385636661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}