{"id":"W4404230727","doi":"10.1093/neuonc/noae165.0607","title":"IMMU-14. TRANS-SPECIES ANALYSIS OF REPLICATION-REPAIR DEFICIENT (RRD) MEDULLOBLASTOMA AND RESPONSE TO IMMUNE CHECKPOINT INHIBITION: AN IRRDC REPORT","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hospital for Sick Children","funders":"","keywords":"Immune checkpoint; Replication (statistics); Immune system; Cancer research; Biology; Immunotherapy; Immunology; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089015,0.0002889952,0.0003099402,0.0007833462,0.0002321085,0.0003274894,0.0002034568,0.0003290746,0.001961211],"category_scores_gemma":[0.0001831113,0.0001375068,0.0003832658,0.0003585592,0.0002758277,0.0001085026,0.0003259186,0.0003257431,0.000550831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003605093,"about_ca_system_score_gemma":0.0001608231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000840903,"about_ca_topic_score_gemma":0.00090428,"domain_scores_codex":[0.9997831,0.00002598596,0.00002048712,0.00007301598,0.00004990338,0.0000474936],"domain_scores_gemma":[0.9997709,0.00002412452,0.00006973749,0.00004703444,0.00002658523,0.00006159661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000827191,0.00009226838,0.02319082,0.00006783574,0.00003493983,0.0003766434,0.00005292619,0.00006322775,0.9713873,0.00003565006,0.0001339031,0.00373738],"study_design_scores_gemma":[0.00003856367,0.002067647,0.3425878,0.0000135696,0.0001583831,0.005202257,0.0002115664,0.001010695,0.6436483,0.00009034249,0.004957544,0.00001328147],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993898,0.001388276,0.001410865,0.00005815362,0.00001875909,0.00003844306,0.002225495,0.0001114344,0.0008506615],"genre_scores_gemma":[0.9949024,0.0003756969,0.001115192,0.0000463132,0.000008851285,0.00003884036,0.002331545,0.0000350345,0.001146168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961211,"threshold_uncertainty_score":0.006560862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242567763184399,"score_gpt":0.3205111076496576,"score_spread":0.2962543313312177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}