{"id":"W4404230748","doi":"10.1093/neuonc/noae165.1252","title":"TMIC-75. ICAM-1 PROMOTES AN IMMUNOSUPPRESSIVE LANDSCAPE IN GLIOBLASTOMAS BY REGULATING THE PHENOTYPIC POLARIZATION STATE OF TUMOR ASSOCIATED MACROPHAGES","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Western Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Phenotype; ICAM-1; Glioblastoma; Cancer research; Polarization (electrochemistry); Biology; Immunology; Chemistry; Genetics; Gene; Cell adhesion molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003158452,0.0001726271,0.000211074,0.00006200371,0.00006753516,0.00003553792,0.0002897946,0.0001367718,0.00002937971],"category_scores_gemma":[0.0006025163,0.0001426177,0.00006724842,0.0002434326,0.0001308138,0.00001079589,0.0001389524,0.0002274234,0.000004327123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003911288,"about_ca_system_score_gemma":0.0001970636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002720955,"about_ca_topic_score_gemma":0.00004805413,"domain_scores_codex":[0.9982978,0.0005159571,0.0003523464,0.0004154855,0.0001405754,0.0002777981],"domain_scores_gemma":[0.9991772,0.0001745232,0.000185388,0.0003194307,0.00008642415,0.00005710332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001774169,0.0001618803,0.002945961,0.00003155136,0.00004676572,0.00004564687,0.0003851673,0.0002946817,0.9913497,0.0000211887,0.0008263426,0.003713704],"study_design_scores_gemma":[0.0006730291,0.001061219,0.002637705,0.00004519715,0.00004166664,0.00002621255,0.00008906263,0.003113636,0.9898278,0.000298187,0.002018716,0.0001676028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969009,0.001832255,0.0000872177,0.0002349102,0.0002715955,0.0003140565,0.0001543443,0.00004206951,0.0001626669],"genre_scores_gemma":[0.999187,0.00002253059,0.00008505835,0.0002403527,0.00008349912,0.00003931232,0.000242085,0.00004355924,0.00005661364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003546101,"threshold_uncertainty_score":0.5815779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007259614208771409,"score_gpt":0.2599395207956728,"score_spread":0.2526799065869014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}