{"id":"W4404230831","doi":"10.1093/neuonc/noae165.0411","title":"CTNI-44. NCT03643549 PHASE IB/II TRIAL: EFFICACY, SAFETY, AND BIOLOGICAL MECHANISMS OF OBJECTIVE RESPONSES IN RECURRENT GBM PATIENTS WITH UNMETHYLATED MGMT PROMOTER TREATED WITH SEQUENTIAL BORTEZOMIB AND TEMOZOLOMIDE","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Temozolomide; Bortezomib; Medicine; Oncology; Phases of clinical research; Internal medicine; Glioblastoma; Cancer research; Pharmacology; Clinical trial; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001746139,0.001632821,0.002461516,0.0006989221,0.0005262741,0.001215021,0.0009328874,0.00144016,0.007197324],"category_scores_gemma":[0.0009050589,0.0005298314,0.001138503,0.0007302987,0.0009062734,0.0006354537,0.0004799577,0.002344122,0.001456637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001652968,"about_ca_system_score_gemma":0.002695287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00233215,"about_ca_topic_score_gemma":0.005819444,"domain_scores_codex":[0.9993642,0.0003159918,0.0000401786,0.00008907213,0.00006576629,0.0001248823],"domain_scores_gemma":[0.999472,0.00004863317,0.0001332551,0.00004217074,0.00003867496,0.0002653449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9012457,0.01371615,0.004143354,0.0009321372,0.00105776,0.0001589512,0.000103421,0.00101217,0.01951254,0.0003223985,0.00532345,0.05247199],"study_design_scores_gemma":[0.7358649,0.2396687,0.01329636,0.0001002408,0.000859159,0.0003533259,0.0000448312,0.001048968,0.003305792,0.0002979222,0.005122123,0.00003774853],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748171,0.007072634,0.000499708,0.0008134549,0.0003774009,0.005720969,0.004334342,0.0002431265,0.006121242],"genre_scores_gemma":[0.9746991,0.002576385,0.001435884,0.00114621,0.0004290041,0.005831269,0.007158567,0.00005676678,0.006666867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007197324,"threshold_uncertainty_score":0.02407742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02547523096669905,"score_gpt":0.3209164149299225,"score_spread":0.2954411839632234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}