{"id":"W4404230872","doi":"10.1093/neuonc/noae165.1285","title":"TMOD-21. MOUSE MODEL TO CONDITIONALLY EXPRESS A DIFFUSE MIDLINE GLIOMA DERIVED MUTATION IN THE ONCOGENIC PHOSPHATASE PPM1D","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mutation; Glioma; Biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005856348,0.001356045,0.0006096448,0.001958953,0.0007130927,0.0007574196,0.001108198,0.002205341,0.009383335],"category_scores_gemma":[0.0002364305,0.0008047363,0.0009465326,0.0007717542,0.001086384,0.0007560423,0.0007891437,0.002645741,0.004128226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053269,"about_ca_system_score_gemma":0.0005521907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009568143,"about_ca_topic_score_gemma":0.001661197,"domain_scores_codex":[0.9990749,0.0000959668,0.0001295923,0.0002899306,0.0002321488,0.0001774622],"domain_scores_gemma":[0.9994639,0.00004825574,0.0001976021,0.00005278701,0.0000405475,0.0001970065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003208458,0.0002848224,0.0003721756,0.0001759173,0.00002234559,0.0006193985,0.00007756454,0.000164206,0.9931411,0.001551494,0.0006160572,0.002654041],"study_design_scores_gemma":[0.0004019504,0.001783301,0.005278726,0.00009207824,0.0001293918,0.004658408,0.0001670091,0.002888005,0.9337268,0.0006029118,0.05022816,0.00004330759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9240552,0.004406526,0.03113257,0.001642089,0.0009395257,0.001078977,0.0174039,0.002459178,0.01688211],"genre_scores_gemma":[0.8477643,0.004314984,0.03543722,0.0007394087,0.0001463304,0.002580546,0.01546124,0.0008282742,0.09272773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009383335,"threshold_uncertainty_score":0.03139031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01451121239881415,"score_gpt":0.2831384317947988,"score_spread":0.2686272193959847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}