{"id":"W4404235280","doi":"10.1016/j.ygyno.2024.10.022","title":"Efficacy and safety of dostarlimab in combination with chemotherapy in patients with dMMR/MSI-H primary advanced or recurrent endometrial cancer in a phase 3, randomized, placebo-controlled trial (ENGOT-EN6-NSGO/GOG-3031/RUBY)","year":2024,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Endometrial and Cervical Cancer Treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"GlaxoSmithKline","keywords":"Medicine; Endometrial cancer; Oncology; Placebo; Internal medicine; Cancer; Chemotherapy; Randomized controlled trial; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001446462,0.0003937278,0.002951247,0.00111215,0.00003396787,0.00001561029,0.0001164786,0.0003067213,0.0005334365],"category_scores_gemma":[0.001741025,0.0002233953,0.0001340298,0.001788405,0.0002502829,0.0001444962,0.00004695722,0.0005293351,0.000002136928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00182955,"about_ca_system_score_gemma":0.000953164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001968425,"about_ca_topic_score_gemma":0.001594341,"domain_scores_codex":[0.9963848,0.0007705346,0.00125261,0.0006753118,0.000419105,0.0004976575],"domain_scores_gemma":[0.9925217,0.006630661,0.000399294,0.0001983819,0.0001191173,0.0001308487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7699783,0.007916722,0.004432613,0.0001401873,0.0003318426,0.000160405,0.0004274448,0.00003684665,0.00002782925,0.00003896675,0.000009352661,0.2164995],"study_design_scores_gemma":[0.9274322,0.04416009,0.02665157,0.0003681378,0.000335026,0.000004643243,0.00006496863,0.0001330923,0.00004680213,0.00009272387,0.0004869588,0.0002237699],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979516,0.001906441,0.00002381165,0.0009709061,0.0007783426,0.01590699,0.00004268832,0.00004352755,0.0008113228],"genre_scores_gemma":[0.9938003,0.00206675,0.0004620607,0.0002511561,0.00009626682,0.003098217,0.00009136189,0.00003304731,0.0001008307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2162757,"threshold_uncertainty_score":0.9109797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376632137920022,"score_gpt":0.3232513664158988,"score_spread":0.3094850450366986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}