{"id":"W4404236532","doi":"10.1093/neuonc/noae165.0526","title":"DDDR-41. A GENOME-WIDE CRISPR/CAS9 SCREEN IN GLIOBLASTOMA STEM CELLS UNVEILS SYNTHETIC LETHAL INTERACTIONS AND RESISTANCE MECHANISMS OF JIN001, A BLOOD-BRAIN BARRIER-PENETRANT HSP90 INHIBITOR","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CRISPR; Penetrant (biochemical); Blood–brain barrier; Glioblastoma; Biology; Cancer research; Neuroscience; Genetics; Gene; Central nervous system; Biotechnology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214118,0.0004716702,0.0005759394,0.000395628,0.0002062279,0.000374744,0.0003779415,0.0004179862,0.002045217],"category_scores_gemma":[0.0001800902,0.0002065444,0.0004237355,0.0003709658,0.0002495497,0.0001281837,0.0002708921,0.000636435,0.0007978829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000464271,"about_ca_system_score_gemma":0.0004575147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002168673,"about_ca_topic_score_gemma":0.003662918,"domain_scores_codex":[0.999589,0.00003497634,0.00005483347,0.0001012953,0.0001581895,0.00006168462],"domain_scores_gemma":[0.9998493,0.00003232396,0.00004278772,0.00002327242,0.00001713647,0.0000351573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005419137,0.00004009529,0.0002046572,0.00003316316,0.000005669285,0.00005807308,0.000007773034,0.0001163177,0.9977449,0.00007517429,0.00012984,0.001529983],"study_design_scores_gemma":[0.00001444638,0.0001987521,0.003533503,0.000005689326,0.00002174047,0.0002363213,0.0000193925,0.001405837,0.9907683,0.00002706492,0.003760189,0.000008845461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553906,0.001245962,0.02360825,0.0002601001,0.00009891323,0.0003351215,0.01119873,0.00177668,0.00608565],"genre_scores_gemma":[0.9544001,0.0008255363,0.0196013,0.0002066572,0.000007265731,0.0002124688,0.01407984,0.0002783568,0.01038857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002168673,"threshold_uncertainty_score":0.006841898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633888542177987,"score_gpt":0.2888286274989048,"score_spread":0.2724897420771249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}