{"id":"W4404236533","doi":"10.1093/neuonc/noae165.0377","title":"CTNI-09. TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY (R/R) PEDIATRIC LOW-GRADE GLIOMA (PLGG): RESULTS FROM PATIENTS ON A DRUG HOLIDAY (DH) IN THE PHASE 2 FIREFLY-1 TRIAL","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Université Laval; McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Refractory (planetary science); Medicine; Internal medicine; Glioma; Firefly protocol; Drug; Oncology; Pharmacology; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008216356,0.0004470703,0.0008923443,0.0001663624,0.0001916987,0.0006474531,0.0003904205,0.0003655721,0.001949001],"category_scores_gemma":[0.0006425829,0.0001571996,0.0006630648,0.0002349624,0.0003981969,0.0003557356,0.0002133472,0.001295395,0.0004840853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008913577,"about_ca_system_score_gemma":0.0008900304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695767,"about_ca_topic_score_gemma":0.007155763,"domain_scores_codex":[0.999685,0.0001501697,0.0000163875,0.0000453942,0.00003508056,0.00006787087],"domain_scores_gemma":[0.9994994,0.00006211076,0.00009545177,0.00004001325,0.00002731864,0.0002756471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5521181,0.01634025,0.04109909,0.001141306,0.001909481,0.0005985504,0.0005099966,0.002636031,0.06173959,0.000515268,0.01616131,0.305231],"study_design_scores_gemma":[0.3200924,0.4958315,0.1464404,0.0002184498,0.001887125,0.002149076,0.0003931939,0.002645501,0.01291885,0.0004895165,0.01684998,0.00008405965],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934189,0.002975176,0.0001143303,0.0003117932,0.00005963955,0.0001698184,0.0009298639,0.0000379685,0.00198259],"genre_scores_gemma":[0.9937899,0.00156327,0.000419485,0.0004259758,0.00007083145,0.0001603957,0.002274674,0.00001640589,0.001279092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001949001,"threshold_uncertainty_score":0.006520092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02491413140760189,"score_gpt":0.3172169282592737,"score_spread":0.2923027968516718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}