{"id":"W4404237017","doi":"10.1093/neuonc/noae165.0946","title":"EXTH-15. AN EGFRVIII RNA-LNP VACCINE PROTOTYPE ACHIEVES TUMOUR CLEARANCE IN A GBM MOUSE MODEL","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care","funders":"","keywords":"Cancer research; Virology; RNA; Immunology; Medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003475627,0.000689489,0.0005084167,0.0005460685,0.0001705915,0.0003624603,0.0003918086,0.0008518383,0.001553791],"category_scores_gemma":[0.000126171,0.0002214398,0.0004465879,0.0001849988,0.0003936157,0.0003863371,0.0001572579,0.001440106,0.0005784156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004920961,"about_ca_system_score_gemma":0.0003672237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009909472,"about_ca_topic_score_gemma":0.001115992,"domain_scores_codex":[0.99972,0.00003041898,0.00002193016,0.00006963107,0.00007233978,0.00008558448],"domain_scores_gemma":[0.9998465,0.00001744232,0.00004435065,0.0000142656,0.00002094129,0.00005643553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004243577,0.0005639977,0.0001054864,0.00007293447,0.00001701156,0.00004816649,0.00003174842,0.0004787269,0.9951874,0.0002576793,0.0002964282,0.002516142],"study_design_scores_gemma":[0.0001457339,0.006203145,0.0008375184,0.0000151314,0.00003823021,0.0001740678,0.00002758826,0.002030202,0.9869453,0.00008754712,0.003486828,0.000008560948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849904,0.001231712,0.008738064,0.0003648349,0.0001949126,0.0002627001,0.001521974,0.0004879434,0.002207376],"genre_scores_gemma":[0.9846973,0.001117731,0.005972168,0.0001619274,0.00002924404,0.0003474275,0.001895651,0.00009223189,0.005686303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553791,"threshold_uncertainty_score":0.005198002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514740364101042,"score_gpt":0.3374182770290223,"score_spread":0.3122708733880118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}