{"id":"W4404237050","doi":"10.1093/neuonc/noae165.0660","title":"IMMU-69. THERAPEUTIC WINDOW ENABLING ERADICATION OF RESIDUAL GLIOMA STEM CELLS BY INTRACRANIAL NK CELL THERAPY FOLLOWING TEMOZOLOMIDE-INDUCED TUMOUR DEPOPULATION – A POSSIBLE ROLE OF CYTOTOXIC EXTRACELLULAR VESICLES","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Temozolomide; Extracellular vesicles; Cytotoxic T cell; Glioma; Cancer research; Glioblastoma; Stem cell; Cell; Chemistry; Medicine; Cell biology; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000708853,0.0002794298,0.0002707632,0.0001158347,0.00007104548,0.0002094521,0.0001257385,0.0002013483,0.001005143],"category_scores_gemma":[0.0000440553,0.00006923464,0.0001646132,0.00007200205,0.0001810538,0.0001552791,0.0001222035,0.0003914534,0.0002382955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001739704,"about_ca_system_score_gemma":0.0001415205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005326967,"about_ca_topic_score_gemma":0.0006908492,"domain_scores_codex":[0.9999427,0.000007019814,0.000003347186,0.00001118915,0.00001143345,0.00002434583],"domain_scores_gemma":[0.9999769,0.000003308679,0.000006796443,0.000002832007,0.000002419995,0.000007865883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004025997,0.00009158077,0.000141208,0.0000450593,0.000005020675,0.0000624535,0.00001669919,0.0001381641,0.9962782,0.0001416246,0.00005388636,0.00262355],"study_design_scores_gemma":[0.00004776365,0.002515728,0.002027098,0.000004022082,0.00002046294,0.000245008,0.00002065022,0.0010548,0.9921923,0.00003449627,0.001834012,0.00000356576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970157,0.0008217499,0.0009147881,0.00004088323,0.0000262386,0.00003143951,0.0001803359,0.00005440442,0.0009144309],"genre_scores_gemma":[0.9979501,0.0002828052,0.0006934892,0.00001654498,0.000005339336,0.00001888945,0.0001809665,0.000005181166,0.0008465954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005143,"threshold_uncertainty_score":0.003362536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328378312796306,"score_gpt":0.2658807028766829,"score_spread":0.2525969197487198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}