{"id":"W4404237084","doi":"10.1093/neuonc/noae165.0234","title":"STEM-08. LIPID SATURATION HOMEOSTASIS PRESENTS A TARGETABLE VULNERABILITY IN MYC-AMPLIFIED GROUP 3 MEDULLOBLASTOMA","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medulloblastoma; Homeostasis; Saturation (graph theory); Vulnerability (computing); Biology; Internal medicine; Cancer research; Medicine; Cell biology; Computer science; Mathematics; Computer security; Combinatorics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008488426,0.0002115111,0.0001591442,0.0003016056,0.0001335943,0.0002593345,0.0001199161,0.0002476509,0.001721284],"category_scores_gemma":[0.0001109285,0.00009428991,0.0002170006,0.0001814145,0.0001945093,0.0001456916,0.0001812595,0.0003843161,0.0003319055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003566233,"about_ca_system_score_gemma":0.0001712992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398508,"about_ca_topic_score_gemma":0.002075332,"domain_scores_codex":[0.9999281,0.00000493057,0.000004726919,0.00001948613,0.00002893317,0.00001374586],"domain_scores_gemma":[0.9999435,0.000007654801,0.00002108984,0.000004966294,0.000007726178,0.00001500974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001860902,0.00001778972,0.002257221,0.00005431815,0.00001164336,0.0002580442,0.00003057419,0.00006951785,0.9924508,0.00009937689,0.0001301357,0.004434629],"study_design_scores_gemma":[0.00002421075,0.00047706,0.06364587,0.0000201248,0.00005899807,0.002398174,0.0001595825,0.001567197,0.9215357,0.0003270273,0.009774927,0.00001109673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931018,0.001321301,0.002369999,0.0001499858,0.00002305438,0.00003336828,0.001606456,0.0002265443,0.001167432],"genre_scores_gemma":[0.9945568,0.0008558492,0.00125001,0.0001176389,0.000004320907,0.00003064559,0.001516003,0.00003923579,0.001629586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001721284,"threshold_uncertainty_score":0.005758286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629925913622013,"score_gpt":0.2873422987769701,"score_spread":0.2710430396407499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}