{"id":"W4404237190","doi":"10.1093/neuonc/noae165.0375","title":"CTNI-07. LONG-TERM EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TRK FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Central nervous system; Medicine; Term (time); Neuroscience; Internal medicine; Biology; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005571814,0.000684628,0.002060938,0.001577905,0.0002422539,0.001660674,0.001271553,0.0005717232,0.003343159],"category_scores_gemma":[0.005276116,0.0003174928,0.003246848,0.003129858,0.0003920775,0.001071751,0.0005139619,0.001405523,0.0009078904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001983051,"about_ca_system_score_gemma":0.001794297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002404249,"about_ca_topic_score_gemma":0.00742915,"domain_scores_codex":[0.9975228,0.0007734944,0.000354509,0.000350244,0.0008371332,0.0001618109],"domain_scores_gemma":[0.9927835,0.002038047,0.003404433,0.0002998855,0.001011963,0.0004620411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.09484199,0.0009201245,0.3433014,0.01991365,0.04086922,0.0005973542,0.0002943147,0.006663523,0.01160959,0.001067741,0.04110985,0.4388112],"study_design_scores_gemma":[0.02727848,0.02606823,0.7699639,0.003765204,0.06758595,0.003987303,0.0001960406,0.006331895,0.005443323,0.0009943179,0.08808958,0.0002958344],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6596528,0.2234749,0.003108222,0.002097645,0.0003147258,0.002539455,0.08288973,0.0004342992,0.02548836],"genre_scores_gemma":[0.8481945,0.05009496,0.004282878,0.002563949,0.0005874396,0.001632427,0.08879234,0.0001518334,0.003699622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005571814,"threshold_uncertainty_score":0.02946693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009264451921468471,"score_gpt":0.2630729499344481,"score_spread":0.2538084980129797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}