{"id":"W4404237190","doi":"10.1093/neuonc/noae165.0375","title":"CTNI-07. LONG-TERM EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TRK FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Trk receptor; Central nervous system; Medicine; Term (time); Neuroscience; Internal medicine; Biology; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001325658,0.0002254124,0.0008041296,0.000457113,0.00004510464,0.00001906061,0.00007386585,0.0001366087,0.00007349194],"category_scores_gemma":[0.00002123712,0.0001623522,0.00009597852,0.0007958027,0.00007466294,0.00008335723,0.00006177383,0.0002184595,0.000007523032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003620008,"about_ca_system_score_gemma":0.0001585445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001105814,"about_ca_topic_score_gemma":0.0001986716,"domain_scores_codex":[0.9981684,0.000243392,0.0004771882,0.0005315213,0.0002447923,0.0003346723],"domain_scores_gemma":[0.9990809,0.000189829,0.0001339132,0.0003143555,0.00007437414,0.0002066161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002249456,0.002232911,0.9568846,0.0002303225,0.000526306,0.002063039,0.0004223763,0.00009190413,0.00460647,0.00002394973,0.00007156532,0.03059712],"study_design_scores_gemma":[0.007230847,0.003934224,0.9851971,0.0002245912,0.001517542,0.00007834456,0.00005121528,0.0003033665,0.00105914,5.342318e-7,0.0002820765,0.0001209656],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979322,0.0002336053,0.000008434508,0.000239625,0.0001832015,0.0009507853,0.00004204789,0.00008849915,0.0003215992],"genre_scores_gemma":[0.9991136,0.00003736777,0.00007066379,0.0001304923,0.00005413679,0.00003439693,0.0005238946,0.00003087406,0.000004595426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03047615,"threshold_uncertainty_score":0.6620532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009264451921468471,"score_gpt":0.2630729499344481,"score_spread":0.2538084980129797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}