{"id":"W4404237229","doi":"10.1093/neuonc/noae165.0235","title":"STEM-09. A GROUP 3 MEDULLOBLASTOMA STEM CELL PROGRAM IS MAINTAINED BY OTX2-MEDIATED ALTERNATIVE SPLICING","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University; University of Toronto; University of Manitoba","funders":"","keywords":"Medulloblastoma; Stem cell; RNA splicing; Group (periodic table); Biology; Alternative splicing; Cell biology; Genetics; Chemistry; Gene; Exon; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139068,0.0002476724,0.00026644,0.0003007127,0.000325718,0.0006474032,0.0001949146,0.0002775397,0.003322605],"category_scores_gemma":[0.0001452317,0.0001813939,0.0002910014,0.0002952463,0.0003108869,0.0001960963,0.0004005087,0.0005756552,0.001075762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004087141,"about_ca_system_score_gemma":0.0003876025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006578,"about_ca_topic_score_gemma":0.001980333,"domain_scores_codex":[0.9998069,0.00000774897,0.000007739,0.00006562197,0.00007859001,0.00003341372],"domain_scores_gemma":[0.999856,0.00001791088,0.00005201435,0.00001238225,0.00002042593,0.00004130991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009917032,0.00001241719,0.002435385,0.00007452866,0.00001055639,0.0001202816,0.00006950937,0.000143144,0.989423,0.0007494108,0.000548253,0.006314354],"study_design_scores_gemma":[0.00004597839,0.0002285628,0.1075355,0.00004545382,0.00007041825,0.0009369145,0.0002776681,0.007377638,0.839698,0.001124189,0.0426351,0.00002473177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584139,0.001994544,0.01736333,0.0002814861,0.0001343267,0.00009534362,0.01126605,0.001595242,0.008855826],"genre_scores_gemma":[0.9702965,0.0006330814,0.006109768,0.0003246837,0.00002569313,0.00008076378,0.01276526,0.0003366459,0.009427653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003322605,"threshold_uncertainty_score":0.01111519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256463644469216,"score_gpt":0.2906526383074274,"score_spread":0.2780880018627352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}