{"id":"W4404237307","doi":"10.1093/neuonc/noae165.0406","title":"CTNI-39. UPDATE ON GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Glioblastoma; Agile software development; Medicine; Computer science; Oncology; Internal medicine; Cancer research; Software engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008167558,0.001175056,0.002215203,0.0007203295,0.0004041307,0.001738984,0.001231662,0.001517949,0.005696787],"category_scores_gemma":[0.007666963,0.000300721,0.002666214,0.001009576,0.0005923809,0.00141935,0.0008458155,0.004723921,0.001458317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001405556,"about_ca_system_score_gemma":0.002433186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00137639,"about_ca_topic_score_gemma":0.005261134,"domain_scores_codex":[0.9979582,0.001294635,0.000141813,0.0001699446,0.000297654,0.0001377144],"domain_scores_gemma":[0.9963702,0.001355236,0.0005954187,0.0002618357,0.0005636047,0.0008537311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1112326,0.003198747,0.002928162,0.005523629,0.003487191,0.0002637189,0.0002585869,0.004929543,0.008243144,0.003736222,0.1162441,0.7399544],"study_design_scores_gemma":[0.4891782,0.118848,0.02383977,0.006545557,0.006325848,0.001069703,0.0002066187,0.005384611,0.006140611,0.01154832,0.3306209,0.0002919461],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4396572,0.2540268,0.03212483,0.08098479,0.01008571,0.02847935,0.04995142,0.003689715,0.1010003],"genre_scores_gemma":[0.6080949,0.1284989,0.06917911,0.06789733,0.0046824,0.04513201,0.04343048,0.001742368,0.03134256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008167558,"threshold_uncertainty_score":0.04319471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04463420761098044,"score_gpt":0.3655379694347403,"score_spread":0.3209037618237598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}