{"id":"W4404237353","doi":"10.1093/neuonc/noae165.1299","title":"TMOD-35. EGFRVIII OVEREXPRESSION AND LOSS OF MOUSE SPECIFIC CDKN2A IN GLIAL CELLS LEADS TO SPONTANEOUS GLIOMAGENESIS IN A NOVEL MOUSE MODEL","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"CDKN2A; Cancer research; Cell biology; Biology; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004172485,0.001199602,0.000432114,0.001811489,0.00045689,0.0006211459,0.0007683881,0.0009741863,0.00341544],"category_scores_gemma":[0.0001105068,0.0005663902,0.000720713,0.0005490005,0.0007423144,0.0004292981,0.0004111845,0.001599485,0.001789174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008154844,"about_ca_system_score_gemma":0.0004677816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386564,"about_ca_topic_score_gemma":0.002445365,"domain_scores_codex":[0.9995009,0.00006575327,0.00005820869,0.0001231002,0.0001527885,0.00009923289],"domain_scores_gemma":[0.9997148,0.00002942737,0.00009150942,0.00004799891,0.00002126166,0.00009507791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000155381,0.0001829886,0.0001347464,0.00004049168,0.00001145705,0.0001865915,0.00003206664,0.0001223571,0.9971653,0.0006777865,0.0002017676,0.001089153],"study_design_scores_gemma":[0.0001315255,0.0008814732,0.001997434,0.00002486952,0.00003717409,0.001114372,0.00005020414,0.001483608,0.9849972,0.0002822119,0.008987268,0.00001270256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610191,0.002323027,0.02020591,0.000675498,0.0001938071,0.0005356587,0.006524044,0.001740349,0.006782499],"genre_scores_gemma":[0.9453431,0.00269506,0.01762635,0.000199328,0.00003555661,0.0008606752,0.005254804,0.0003359676,0.02764912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00341544,"threshold_uncertainty_score":0.01142579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01866232243226399,"score_gpt":0.300250370571499,"score_spread":0.281588048139235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}