{"id":"W4404237353","doi":"10.1093/neuonc/noae165.1299","title":"TMOD-35. EGFRVIII OVEREXPRESSION AND LOSS OF MOUSE SPECIFIC CDKN2A IN GLIAL CELLS LEADS TO SPONTANEOUS GLIOMAGENESIS IN A NOVEL MOUSE MODEL","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"CDKN2A; Cancer research; Cell biology; Biology; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180084,0.0001933859,0.0002831716,0.0002412007,0.00002447464,0.00002283807,0.0001767907,0.0002158325,0.00001653247],"category_scores_gemma":[0.00003578144,0.0001866768,0.0000649026,0.0002016248,0.0000921806,0.000008181857,0.0002655864,0.0001723155,0.00001140266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001720213,"about_ca_system_score_gemma":0.0003123915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003173241,"about_ca_topic_score_gemma":0.001591827,"domain_scores_codex":[0.9984989,0.00008253106,0.0002847732,0.0005964525,0.0001477363,0.0003895842],"domain_scores_gemma":[0.999422,0.00005645125,0.00003811963,0.0002964269,0.00003177388,0.0001552054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001597355,0.0003731638,0.0004190255,0.00005688375,0.00001530702,0.0008932884,0.000185183,0.001905818,0.9910011,0.0000208848,0.0008816742,0.002650365],"study_design_scores_gemma":[0.001838692,0.001265095,0.00009330595,0.00003717677,0.000007336292,0.0001930959,0.0000240142,0.001606317,0.9826886,0.00002266132,0.01205595,0.0001677382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997839,0.00079211,0.0001941473,0.0001612993,0.000103353,0.0003965094,0.0002306302,0.00001195473,0.000270965],"genre_scores_gemma":[0.9976706,0.001020675,0.0005218146,0.0001817116,0.00008667487,0.00006662511,0.00003208843,0.00003847012,0.0003813642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01117427,"threshold_uncertainty_score":0.7612457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01866232243226399,"score_gpt":0.300250370571499,"score_spread":0.281588048139235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}