{"id":"W4404237411","doi":"10.1093/neuonc/noae165.0678","title":"INNV-15. A PIVOTAL, MULTICENTER TRIAL OF FOCUSED ULTRASOUND FOR BLOOD-BRAIN BARRIER DISRUPTION FOR PLASMA-BASED LIQUID BIOPSY IN PATIENTS WITH GLIOBLASTOMA (LIBERATE)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Advanced Radiotherapy Techniques","field":"Physics and Astronomy","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Glioblastoma; Focused ultrasound; Blood–brain barrier; Liquid biopsy; Medicine; Biopsy; Ultrasound; Brain biopsy; Multicenter trial; Multicenter study; Radiology; Pathology; Internal medicine; Cancer research; Randomized controlled trial; Central nervous system; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001626733,0.0002550098,0.0004258266,0.0002194916,0.00005489423,0.00002947935,0.0001466164,0.0001304575,0.00005281743],"category_scores_gemma":[0.00006698167,0.0002182596,0.000156912,0.0002260307,0.0001174779,0.0001723447,0.00001708242,0.0001963439,9.802158e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008775532,"about_ca_system_score_gemma":0.0001903811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001067311,"about_ca_topic_score_gemma":0.00001532024,"domain_scores_codex":[0.9984866,0.0001151029,0.0004565792,0.0004610397,0.0001267422,0.0003539826],"domain_scores_gemma":[0.9979597,0.00144932,0.000188506,0.0002226559,0.0001088763,0.00007091899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2912917,0.005007192,0.01086039,0.0002974273,0.0004317727,0.00001829796,0.001145616,0.0005235866,0.6495295,0.002470232,0.001373991,0.03705032],"study_design_scores_gemma":[0.2669182,0.08914442,0.0004324271,0.0002651899,0.0003354232,0.000004924746,0.00008801402,0.00986078,0.5451575,0.001031374,0.08570037,0.001061411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385202,0.00001041979,0.05726049,0.0002278372,0.0003934611,0.003056623,0.0003827502,0.00009352361,0.00005469199],"genre_scores_gemma":[0.9818824,0.000001082455,0.01603902,0.0001787865,0.0002700723,0.001405813,0.0001077969,0.00008971148,0.00002535483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.104372,"threshold_uncertainty_score":0.8900369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007935530442875571,"score_gpt":0.2828799126506333,"score_spread":0.2749443822077577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}