{"id":"W4404237411","doi":"10.1093/neuonc/noae165.0678","title":"INNV-15. A PIVOTAL, MULTICENTER TRIAL OF FOCUSED ULTRASOUND FOR BLOOD-BRAIN BARRIER DISRUPTION FOR PLASMA-BASED LIQUID BIOPSY IN PATIENTS WITH GLIOBLASTOMA (LIBERATE)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Advanced Radiotherapy Techniques","field":"Physics and Astronomy","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Glioblastoma; Focused ultrasound; Blood–brain barrier; Liquid biopsy; Medicine; Biopsy; Ultrasound; Brain biopsy; Multicenter trial; Multicenter study; Radiology; Pathology; Internal medicine; Cancer research; Randomized controlled trial; Central nervous system; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002632353,0.001250046,0.001706496,0.0002891402,0.0003341594,0.001155676,0.0006726005,0.001090551,0.003578041],"category_scores_gemma":[0.001377414,0.0003681823,0.001455686,0.0003194733,0.0007166247,0.0007181519,0.0005097963,0.001987655,0.0006981605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008390165,"about_ca_system_score_gemma":0.001523356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006568579,"about_ca_topic_score_gemma":0.001840247,"domain_scores_codex":[0.9992195,0.0004363279,0.00004536164,0.0001342609,0.00004543342,0.0001191318],"domain_scores_gemma":[0.9990711,0.0001718416,0.0002400705,0.00006310045,0.00007445318,0.0003793768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9228818,0.007353708,0.003861027,0.001232199,0.001776464,0.00007109984,0.0001038752,0.0005416666,0.007848025,0.0004089301,0.002721012,0.05120027],"study_design_scores_gemma":[0.7304395,0.2512442,0.008889947,0.0001587695,0.001305532,0.0001513275,0.00005430091,0.0006803339,0.002316399,0.000550087,0.004177698,0.00003178752],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754937,0.01307119,0.001003221,0.001621443,0.0005055745,0.003293714,0.002127731,0.0001331496,0.002750167],"genre_scores_gemma":[0.9810358,0.003692496,0.002550213,0.002288188,0.000348067,0.004198155,0.003281442,0.00003384992,0.002571803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003578041,"threshold_uncertainty_score":0.01392138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007935530442875571,"score_gpt":0.2828799126506333,"score_spread":0.2749443822077577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}