{"id":"W4404237499","doi":"10.1093/neuonc/noae165.1079","title":"RTID-03. A MULTICENTER, RANDOMIZED, CONTROLLED TRIAL OF FOCUSED-ULTRASOUND-MEDIATED BLOOD-BRAIN BARRIER DISRUPTION PLUS SYSTEMIC PEMBROLIZUMAB FOR PATIENTS WITH NSCLC BRAIN METASTASES (LIMITLESS)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Pembrolizumab; Medicine; Randomized controlled trial; Internal medicine; Oncology; Blood–brain barrier; Cancer; Immunotherapy; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002513738,0.001960081,0.00314056,0.0004790179,0.0005330962,0.001467403,0.001276897,0.001834912,0.01070653],"category_scores_gemma":[0.002895555,0.0007697429,0.002374126,0.0005310762,0.0009863277,0.001198669,0.0005105574,0.003152695,0.001344652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001089818,"about_ca_system_score_gemma":0.001678578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408221,"about_ca_topic_score_gemma":0.002920492,"domain_scores_codex":[0.9987374,0.0007161439,0.0001084905,0.000220925,0.00007439956,0.0001426784],"domain_scores_gemma":[0.9988822,0.0002618929,0.0003280751,0.00009225259,0.0001151091,0.0003204034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.983124,0.003328153,0.0003631387,0.001093319,0.001475309,0.00002176625,0.00002605059,0.0001642079,0.001566052,0.000162238,0.001093142,0.007582614],"study_design_scores_gemma":[0.9774607,0.02063719,0.0004414615,0.00003027818,0.0005394378,0.00001376516,0.00001023121,0.0001871083,0.0001654674,0.00008542931,0.0004217788,0.000007235161],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509463,0.01439022,0.001778327,0.002169806,0.002211633,0.01628581,0.00629764,0.0005301008,0.005390149],"genre_scores_gemma":[0.9610196,0.003325154,0.00397613,0.002480657,0.0009067387,0.02007041,0.002829647,0.00005484195,0.005336729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01070653,"threshold_uncertainty_score":0.03581685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195656137698772,"score_gpt":0.286510960461027,"score_spread":0.2745543990840392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}