{"id":"W4404237690","doi":"10.1093/neuonc/noae165.0420","title":"CTNI-53. A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH ADULT-TYPE DIFFUSE GLIOMA WITH AN IDH1/2 MUTATION (INDIGO): UPDATED EFFICACY RESULTS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Placebo; Glioma; Double blinded; Medicine; Internal medicine; IDH1; Troponin I; Oncology; Mutation; Pathology; Biology; Genetics; Cancer research; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002843751,0.0004096374,0.001167011,0.0004740991,0.00006673473,0.00005079119,0.0001529908,0.0001934449,0.00002376103],"category_scores_gemma":[0.000330708,0.000273142,0.00008700565,0.001467417,0.0001744094,0.000205333,0.00005236569,0.0003096329,0.00002633985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004143696,"about_ca_system_score_gemma":0.0004462712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006770012,"about_ca_topic_score_gemma":0.00184601,"domain_scores_codex":[0.9967486,0.0005387994,0.00083984,0.0008430572,0.0006085411,0.00042111],"domain_scores_gemma":[0.997537,0.0008707283,0.0003298165,0.0005600411,0.0004499646,0.0002524347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9406039,0.03211375,0.01252417,0.00004414269,0.0007886947,0.006343596,0.002421332,0.0001964019,0.0006411595,0.00005589029,0.000211338,0.004055596],"study_design_scores_gemma":[0.9214687,0.06155013,0.01198009,0.000133705,0.001492874,0.000100199,0.0008456417,0.0005027865,0.00154846,0.000007556846,0.0001438884,0.0002259828],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920757,0.00007259633,0.000004966967,0.0004763542,0.0005399022,0.006390558,0.00006063653,0.0001387334,0.0002404816],"genre_scores_gemma":[0.9988912,0.00001315181,0.000123369,0.00008803228,0.00006502836,0.0003233194,0.0004390254,0.00005475672,0.000002065645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02943638,"threshold_uncertainty_score":0.9999721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741043637994282,"score_gpt":0.3456325533764556,"score_spread":0.3182221169965128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}