{"id":"W4404237690","doi":"10.1093/neuonc/noae165.0420","title":"CTNI-53. A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH ADULT-TYPE DIFFUSE GLIOMA WITH AN IDH1/2 MUTATION (INDIGO): UPDATED EFFICACY RESULTS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Placebo; Glioma; Double blinded; Medicine; Internal medicine; IDH1; Troponin I; Oncology; Mutation; Pathology; Biology; Genetics; Cancer research; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002594964,0.001619193,0.002538795,0.0006846299,0.000455094,0.001370429,0.001172829,0.00142482,0.006641899],"category_scores_gemma":[0.001524311,0.0006696517,0.002002283,0.0008164046,0.001111111,0.0008926314,0.0003402984,0.002909557,0.001127769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001120555,"about_ca_system_score_gemma":0.002232385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313118,"about_ca_topic_score_gemma":0.006368396,"domain_scores_codex":[0.9990913,0.0004696402,0.00005843195,0.000150877,0.00008867747,0.0001410186],"domain_scores_gemma":[0.999331,0.0001094311,0.0002100289,0.00004994675,0.0000644199,0.0002351225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9259834,0.006555368,0.001368194,0.001753597,0.002090125,0.0000778481,0.00009361491,0.0006525419,0.01139763,0.0003400103,0.004316888,0.04537072],"study_design_scores_gemma":[0.9493582,0.0430241,0.002913538,0.00007038847,0.001017182,0.00006041138,0.00001866696,0.0003177,0.0009078266,0.0001902509,0.002095852,0.00002587122],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.914808,0.03303641,0.002698555,0.002574726,0.001196706,0.02090486,0.0117731,0.0008370534,0.01217065],"genre_scores_gemma":[0.9591837,0.008212794,0.003999301,0.003105623,0.0004294867,0.01360607,0.00559211,0.00008992016,0.005781065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006641899,"threshold_uncertainty_score":0.02221936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02741043637994282,"score_gpt":0.3456325533764556,"score_spread":0.3182221169965128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}