{"id":"W4404237702","doi":"10.1093/neuonc/noae165.0606","title":"IMMU-13. TRANS-SPECIES STUDY OF IDH-MUTANT REPLICATION-REPAIR DEFICIENT HIGH-GRADE GLIOMAS (RRD-HGG) AND RESPONSE TO COMBINED TARGETED AND IMMUNOTHERAPY: AN IRRDC STUDY","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Mutant; Immunotherapy; Replication (statistics); Cancer research; Biology; Medicine; Immune system; Virology; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007500727,0.00059642,0.0005730906,0.000701863,0.0002364043,0.0003905415,0.0004685931,0.0004627465,0.001670852],"category_scores_gemma":[0.0002025859,0.0002302339,0.0005138049,0.0003775751,0.000475125,0.0002163981,0.0002276119,0.0006681466,0.0005504789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007175988,"about_ca_system_score_gemma":0.0002837197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0023693,"about_ca_topic_score_gemma":0.001858962,"domain_scores_codex":[0.9996823,0.00007189874,0.00001640156,0.00009114179,0.00006031094,0.00007792143],"domain_scores_gemma":[0.9996289,0.00003415875,0.00008652946,0.00007474738,0.00003613785,0.000139565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01970442,0.00388451,0.05082329,0.0002691581,0.0002706869,0.001343006,0.0002847391,0.000446165,0.907829,0.0001693454,0.0003836494,0.01459207],"study_design_scores_gemma":[0.001607066,0.104717,0.5673595,0.00003556707,0.0008456271,0.008249947,0.0006584586,0.002096075,0.3061563,0.000132375,0.008087678,0.00005446032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969999,0.0009502693,0.0002943823,0.00003072608,0.000009414146,0.00008635657,0.0007931953,0.0000258314,0.0008098423],"genre_scores_gemma":[0.995402,0.0004816022,0.0004550632,0.00004492789,0.00001509287,0.00006085465,0.001867994,0.00001652086,0.001655983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0023693,"threshold_uncertainty_score":0.005589485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02617359090714917,"score_gpt":0.3194596069418693,"score_spread":0.2932860160347201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}