{"id":"W4404237739","doi":"10.1093/neuonc/noae165.0444","title":"CTNI-77. PHASE 1 DOSE FINDING STUDY EVALUATING THE SAFETY, TOLERABILITY, AND EFFICACY OF IOPOFOSINE I 131 IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS WITH INOPERABLE RELAPSED OR REFRACTORY HIGH-GRADE GLIOMAS: A TRIAL-IN-PROGRESS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Tolerability; Medicine; Refractory (planetary science); Oncology; Internal medicine; Adverse effect; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001299092,0.001767032,0.001730939,0.000383497,0.0004265222,0.001261857,0.001159706,0.001400894,0.004590019],"category_scores_gemma":[0.0009712138,0.0006024052,0.001054136,0.0004117855,0.001011432,0.0007802266,0.0002957123,0.003526919,0.001283115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001836535,"about_ca_system_score_gemma":0.003245625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004820121,"about_ca_topic_score_gemma":0.01651535,"domain_scores_codex":[0.9996561,0.0001522487,0.0000123925,0.00004652016,0.00004107755,0.00009161091],"domain_scores_gemma":[0.9993997,0.00007842311,0.0001134446,0.00003540448,0.00004507306,0.0003280732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6803008,0.05920769,0.007544158,0.002001977,0.002140841,0.000971628,0.0006620684,0.004655726,0.08338025,0.001407184,0.01919417,0.1385335],"study_design_scores_gemma":[0.5852162,0.3867561,0.007897099,0.0001289171,0.0006248087,0.0008594525,0.0001364157,0.001337342,0.006506442,0.0003525093,0.01012706,0.00005771616],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794958,0.004764218,0.000753669,0.000968297,0.0001958394,0.00459605,0.003176612,0.0002543025,0.00579514],"genre_scores_gemma":[0.9648014,0.006776479,0.003603712,0.001969926,0.000208837,0.006383711,0.007757118,0.0001140864,0.008384745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004820121,"threshold_uncertainty_score":0.01535511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03368687855500614,"score_gpt":0.3660909497717914,"score_spread":0.3324040712167852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}