{"id":"W4404238107","doi":"10.1093/neuonc/noae165.0019","title":"EPCO-20. MUTANT IDH INHIBITORS INDUCE LINEAGE DIFFERENTIATION IN IDH-MUTANT OLIGODENDROGLIOMA","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University Health Network; Princess Margaret Cancer Centre; Montreal Neurological Institute and Hospital","funders":"","keywords":"Oligodendroglioma; Mutant; Lineage (genetic); Biology; Genetics; Gene; Glioma; Astrocytoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179575,0.0001551023,0.0001803663,0.0001760032,0.0001106178,0.0002622346,0.0001311527,0.000159064,0.001697368],"category_scores_gemma":[0.0001228164,0.00007476191,0.0001161946,0.0001048127,0.0001396033,0.00008240682,0.0001132365,0.0003931134,0.00041863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002278379,"about_ca_system_score_gemma":0.000223335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263662,"about_ca_topic_score_gemma":0.002895749,"domain_scores_codex":[0.9999094,0.00001157097,0.000007780979,0.00002070285,0.00002717577,0.00002340108],"domain_scores_gemma":[0.999922,0.00001735676,0.00001303019,0.000009489175,0.00001136246,0.00002678696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002992841,0.00008899516,0.0008133532,0.00003942442,0.00001283575,0.00005616495,0.00002983421,0.0002211462,0.9923453,0.00009825702,0.0004374519,0.005557868],"study_design_scores_gemma":[0.00003449504,0.0007243809,0.01069148,0.000005903489,0.0000236256,0.0001899177,0.00004014261,0.001463923,0.9816123,0.00005132703,0.005158756,0.000003809213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943448,0.0007162596,0.001202913,0.00008435305,0.00003146625,0.00003984906,0.0009965256,0.00009837569,0.002485574],"genre_scores_gemma":[0.992967,0.0003506495,0.001634241,0.0001224085,0.000007561557,0.00005145277,0.001632306,0.00003588209,0.003198466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001697368,"threshold_uncertainty_score":0.005678236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02048866232450902,"score_gpt":0.3009695805885792,"score_spread":0.2804809182640702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}