{"id":"W4404252863","doi":"10.1038/s43587-024-00731-y","title":"Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability","year":2024,"lang":"en","type":"article","venue":"Nature Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; HORIZON EUROPE Framework Programme; National Institutes of Health; Skånes universitetssjukhus; Parkinsonfonden; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; Hjärnfonden; European Commission; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; University College London; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Weston Brain Institute; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Australian Government; Lunds Universitet; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Faculty of Medicine, McGill University; McGill University","keywords":"Dementia; Medicine; Amyloid (mycology); Disease; Positron emission tomography; Cohort; Internal medicine; Pathology; Cerebrospinal fluid; Oncology; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004148367,0.0001908261,0.0003502687,0.0002324046,0.00006154416,0.00003226521,0.00009902134,0.0001720557,0.0001058944],"category_scores_gemma":[0.0005009269,0.000148268,0.0003114211,0.000635653,0.0001166284,0.0001119283,0.0001054658,0.0005118349,0.00004312464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001015005,"about_ca_system_score_gemma":0.0005424721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005510807,"about_ca_topic_score_gemma":0.000006809102,"domain_scores_codex":[0.9980587,0.0001198131,0.0003881812,0.000539346,0.0005279501,0.0003660625],"domain_scores_gemma":[0.998211,0.0003055522,0.00004380548,0.0004167711,0.0001562397,0.0008666406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001005664,0.0009115641,0.933216,0.0006327947,0.01329,0.001356856,0.00009207231,0.00001585105,0.00005299379,0.0001257242,0.003570631,0.04572983],"study_design_scores_gemma":[0.002312492,0.0003501854,0.9724652,0.002928666,0.007341392,0.0000314696,0.00007776786,0.007153636,0.004170096,0.0004940279,0.002279552,0.0003954791],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9439616,0.0519464,0.00001333319,0.002215052,0.0003999874,0.0009973758,0.00010975,0.0001297231,0.0002268024],"genre_scores_gemma":[0.9974741,0.0001447616,0.001761494,0.0002347767,0.000230233,0.0000571755,0.00005446008,0.00003482978,0.000008161042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05351253,"threshold_uncertainty_score":0.6046194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08761012361629247,"score_gpt":0.4194927483907729,"score_spread":0.3318826247744805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}