{"id":"W4404252863","doi":"10.1038/s43587-024-00731-y","title":"Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability","year":2024,"lang":"en","type":"article","venue":"Nature Aging","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; HORIZON EUROPE Framework Programme; National Institutes of Health; Skånes universitetssjukhus; Parkinsonfonden; Fondation Brain Canada; Familjen Erling-Perssons Stiftelse; Hjärnfonden; European Commission; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; University College London; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Weston Brain Institute; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Australian Government; Lunds Universitet; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Faculty of Medicine, McGill University; McGill University","keywords":"Dementia; Medicine; Amyloid (mycology); Disease; Positron emission tomography; Cohort; Internal medicine; Pathology; Cerebrospinal fluid; Oncology; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003170155,0.0006262607,0.0005043496,0.001855801,0.0003389261,0.001212971,0.0004482944,0.0005934329,0.001050674],"category_scores_gemma":[0.0131376,0.0002551395,0.0006820169,0.001299396,0.0003833268,0.0009897731,0.000686055,0.0005687843,0.0003691305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002905359,"about_ca_system_score_gemma":0.0002793068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002042609,"about_ca_topic_score_gemma":0.001570907,"domain_scores_codex":[0.9974106,0.001188177,0.0002610377,0.0006260332,0.0003551604,0.0001590741],"domain_scores_gemma":[0.9944257,0.002390659,0.00184092,0.0005963148,0.0005354743,0.0002109777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003036601,0.00002030676,0.9931752,0.00001460419,0.0002612401,0.00007224392,0.0000553273,0.0005101179,0.0004069298,0.00006796196,0.0001568132,0.004955735],"study_design_scores_gemma":[0.00002220138,0.0004291123,0.9864227,0.00001533977,0.0002294332,0.0009722967,0.0001243846,0.009309996,0.001027911,0.0007733291,0.0006514379,0.00002176837],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917978,0.001191809,0.004058897,0.0001645083,0.00005625541,0.00003264291,0.0006563461,0.00005837844,0.001983277],"genre_scores_gemma":[0.9988434,0.00007653695,0.0007779355,0.00002218013,0.00001634521,0.000006552263,0.0001641564,0.000003291968,0.00008950687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003170155,"threshold_uncertainty_score":0.01676553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08761012361629247,"score_gpt":0.4194927483907729,"score_spread":0.3318826247744805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}