{"id":"W4404256912","doi":"10.1093/neuonc/noae165.0887","title":"NCOG-05. HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN THE PHASE 2 FIREFLY-1 (PNOC026) TRIAL OF THE TYPE II RAF INHIBITOR TOVORAFENIB IN RELAPSED/REFRACTORY (R/R) PEDIATRIC LOW-GRADE GLIOMA (PLGG)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University Health Centre; Montreal Children's Hospital; Université Laval","funders":"","keywords":"Refractory (planetary science); Medicine; Quality of life (healthcare); Firefly protocol; Glioma; Health related quality of life; Phases of clinical research; Internal medicine; Oncology; Clinical trial; Cancer research; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001335751,0.0005959748,0.0007156504,0.0001718543,0.0002563081,0.0005091473,0.0004312941,0.0004716388,0.003996976],"category_scores_gemma":[0.0007356387,0.0001954133,0.0007149612,0.0002175847,0.0003767627,0.0003084586,0.0002395607,0.001548621,0.0005081863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008472941,"about_ca_system_score_gemma":0.001068981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00202563,"about_ca_topic_score_gemma":0.008954844,"domain_scores_codex":[0.9994247,0.0003614738,0.00001736683,0.00005062016,0.00006316,0.00008270788],"domain_scores_gemma":[0.9996189,0.00006352527,0.00008442112,0.00002494806,0.000031297,0.0001768499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.825082,0.02252211,0.01881291,0.000751663,0.001446716,0.0001104787,0.00010857,0.001838654,0.0150578,0.0003525794,0.02118177,0.09273463],"study_design_scores_gemma":[0.6606825,0.2393993,0.08121084,0.0001217665,0.00107486,0.0002530805,0.00008665179,0.00277728,0.004323951,0.0004036479,0.009618787,0.0000473598],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857231,0.003025097,0.0002558536,0.0007350726,0.0001988585,0.000890312,0.004836406,0.00008094019,0.004254312],"genre_scores_gemma":[0.9815598,0.001236408,0.001377793,0.0009816498,0.0001144455,0.002484882,0.0083966,0.00001918386,0.003829313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003996976,"threshold_uncertainty_score":0.01337117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05657136340757306,"score_gpt":0.3920085083208276,"score_spread":0.3354371449132545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}