{"id":"W4404256951","doi":"10.1093/neuonc/noae165.0605","title":"IMMU-12. TRANSLATING COMBINED PD1 AND LAG3 INHIBITION FROM PRECLINICAL MODELS TO PATIENTS WITH REFRACTORY, DNA REPLICATION REPAIR DEFICIENT (RRD) GLIOBLASTOMA: AN IRRDC STUDY","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Glioblastoma; Refractory (planetary science); Replication (statistics); Cancer research; DNA repair; Chemistry; Medicine; DNA; Biology; Virology; Biochemistry; Astrobiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001159466,0.0007890351,0.0007315584,0.0003630172,0.000202826,0.0008033924,0.0005014992,0.0005366757,0.002010005],"category_scores_gemma":[0.0002218014,0.0003088694,0.0005007996,0.000311461,0.0005481179,0.0003402681,0.0002935127,0.00179231,0.0008193889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008017435,"about_ca_system_score_gemma":0.00109427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026709,"about_ca_topic_score_gemma":0.002270295,"domain_scores_codex":[0.9997088,0.00008304165,0.00001984774,0.00006465595,0.00004807522,0.00007551711],"domain_scores_gemma":[0.9997805,0.00001881542,0.00004071548,0.00004358704,0.00002338644,0.00009306862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.03391443,0.02229899,0.005531318,0.0008160215,0.0003456159,0.0003468999,0.0002313925,0.002267418,0.8702554,0.0006450803,0.004262238,0.05908518],"study_design_scores_gemma":[0.01744585,0.3573005,0.02603104,0.000115378,0.001028455,0.001574344,0.0003669602,0.006874768,0.5620443,0.000429105,0.0267296,0.0000596334],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916356,0.001917748,0.001552965,0.0003497586,0.0001494302,0.0005312055,0.001353683,0.0001652957,0.002344331],"genre_scores_gemma":[0.9921563,0.001209622,0.001698687,0.0002415133,0.0000503017,0.0004369969,0.002112533,0.00004332892,0.002050811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002010005,"threshold_uncertainty_score":0.006724179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03824706815394288,"score_gpt":0.3245622237392192,"score_spread":0.2863151555852763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}