{"id":"W4404259714","doi":"10.1016/s0140-6736(24)01812-9","title":"Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre","funders":"Merck Sharp and Dohme; Stand Up To Cancer; PharmaMar; Daiichi Sankyo Europe; National Cancer Institute; Rising Tide Foundation; Servier; ECOG-ACRIN Cancer Research Group; Eisai; University of Wisconsin-Madison; Cytokinetics; European Society of Surgical Oncology; Astex Pharmaceuticals; Cancer Australia; U.S. Department of Defense; Musculoskeletal Transplant Foundation; Eli Lilly and Company; National Comprehensive Cancer Network; Jazz Pharmaceuticals; Springworks Therapeutics; National Institutes of Health; Regeneron Pharmaceuticals; National Institute of Dental and Craniofacial Research; Daiichi-Sankyo; MacroGenics; Varian Medical Systems; GlaxoSmithKline; Bristol-Myers Squibb; NRG Oncology; American College of Radiology Imaging Network; Amgen; Pfizer; Karyopharm Therapeutics; PTC Therapeutics","keywords":"Medicine; Surgery; Soft tissue sarcoma; Radiation therapy; Stage (stratigraphy); Pembrolizumab; Soft tissue; Clinical trial; Randomized controlled trial; Sarcoma; Intraoperative radiation therapy; Cancer; Internal medicine; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002713968,0.0001896406,0.001072398,0.0000654033,0.0001330239,0.00007297096,0.0001329966,0.000110146,0.00002603907],"category_scores_gemma":[0.000522099,0.0001037149,0.0001177474,0.0001484131,0.0002224512,0.0001322494,0.00004918668,0.0001383087,3.090904e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002929077,"about_ca_system_score_gemma":0.0001739942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001231892,"about_ca_topic_score_gemma":0.00001680993,"domain_scores_codex":[0.9980481,0.0005361629,0.0006662615,0.0003327024,0.0002110113,0.000205792],"domain_scores_gemma":[0.9884417,0.01066453,0.0002777194,0.0004828026,0.0000504058,0.00008282926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.4001127,0.0007623511,0.03732617,0.00008923049,0.0004681846,0.000004953265,0.0004234188,8.853227e-7,0.0002877099,0.0002863405,0.002362913,0.5578752],"study_design_scores_gemma":[0.4801698,0.001233411,0.4966538,0.0001544453,0.0002831118,0.00001051755,0.00004220107,0.0006281816,0.001186542,0.0001458578,0.01933509,0.0001570908],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703057,0.02265609,0.00001989304,0.003530432,0.0004488626,0.002887407,0.00008906246,0.00002659679,0.00003598279],"genre_scores_gemma":[0.9676028,0.03122452,0.00005637059,0.0002622846,0.0006147308,0.0001041247,0.00006872133,0.00002713992,0.00003930563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5577181,"threshold_uncertainty_score":0.4229372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1584937506253844,"score_gpt":0.3960195755658579,"score_spread":0.2375258249404735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}