{"id":"W4404259714","doi":"10.1016/s0140-6736(24)01812-9","title":"Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; McGill University Health Centre","funders":"Merck Sharp and Dohme; Stand Up To Cancer; PharmaMar; Daiichi Sankyo Europe; National Cancer Institute; Rising Tide Foundation; Servier; ECOG-ACRIN Cancer Research Group; Eisai; University of Wisconsin-Madison; Cytokinetics; European Society of Surgical Oncology; Astex Pharmaceuticals; Cancer Australia; U.S. Department of Defense; Musculoskeletal Transplant Foundation; Eli Lilly and Company; National Comprehensive Cancer Network; Jazz Pharmaceuticals; Springworks Therapeutics; National Institutes of Health; Regeneron Pharmaceuticals; National Institute of Dental and Craniofacial Research; Daiichi-Sankyo; MacroGenics; Varian Medical Systems; GlaxoSmithKline; Bristol-Myers Squibb; NRG Oncology; American College of Radiology Imaging Network; Amgen; Pfizer; Karyopharm Therapeutics; PTC Therapeutics","keywords":"Medicine; Surgery; Soft tissue sarcoma; Radiation therapy; Stage (stratigraphy); Pembrolizumab; Soft tissue; Clinical trial; Randomized controlled trial; Sarcoma; Intraoperative radiation therapy; Cancer; Internal medicine; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002795149,0.002402812,0.004021036,0.0004022167,0.0004773833,0.001523462,0.001266363,0.002963363,0.009746757],"category_scores_gemma":[0.002885421,0.001038995,0.00368095,0.0004782138,0.001933509,0.001667909,0.0005942474,0.004034715,0.001796674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001176551,"about_ca_system_score_gemma":0.001101346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301823,"about_ca_topic_score_gemma":0.002017587,"domain_scores_codex":[0.9986106,0.0008238926,0.0000786724,0.0002421834,0.00007607735,0.0001684725],"domain_scores_gemma":[0.9983671,0.0006005921,0.0003943266,0.0001355159,0.00007997827,0.0004225298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9934611,0.001415087,0.0001855339,0.0002619314,0.0006855708,0.00001394436,0.00001857629,0.0001112418,0.0005914573,0.00004885034,0.0002051768,0.003001508],"study_design_scores_gemma":[0.9609745,0.03694508,0.0007954231,0.00002891847,0.0005206817,0.00001898775,0.00001583346,0.0001892248,0.0001122938,0.0001420149,0.0002443908,0.00001265279],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845546,0.006437019,0.0007031614,0.001015742,0.001026709,0.002491502,0.001216027,0.0000833372,0.002471939],"genre_scores_gemma":[0.9858591,0.002769278,0.00115113,0.001138962,0.0007799838,0.003095905,0.001119942,0.00002606846,0.004059595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009746757,"threshold_uncertainty_score":0.03260618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1584937506253844,"score_gpt":0.3960195755658579,"score_spread":0.2375258249404735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}