{"id":"W4404262247","doi":"10.1101/2024.11.11.622104","title":"Targeting synthetic lethality between non-homologous end joining and radiation in very high-risk SHH medulloblastoma","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Université de Montréal; McGill University; Montreal Clinical Research Institute; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"Lethality; Medulloblastoma; Homologous chromosome; Non-homologous end joining; Synthetic lethality; Cancer research; Homologous recombination; Biology; Genetics; DNA repair; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003208172,0.0003514435,0.0003494419,0.00030349,0.0001435254,0.0003577083,0.0002778579,0.0003192626,0.002176357],"category_scores_gemma":[0.0001822484,0.0001462147,0.0003042085,0.0001239389,0.0003588926,0.0001879264,0.000483568,0.0006201542,0.0003883351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089684,"about_ca_system_score_gemma":0.0002730963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000415279,"about_ca_topic_score_gemma":0.0006511611,"domain_scores_codex":[0.9997631,0.00004153989,0.00001276055,0.00004753397,0.00009588547,0.00003918168],"domain_scores_gemma":[0.9998864,0.00003180098,0.00003317009,0.00001443632,0.000006105374,0.0000281301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001657684,0.00004240565,0.0005829034,0.00007388169,0.00002376469,0.0001358288,0.0000115891,0.0006423903,0.9934155,0.000574801,0.0002128837,0.004118136],"study_design_scores_gemma":[0.00002491275,0.0002985657,0.00315737,0.000009930231,0.00002641357,0.0007722657,0.00002021934,0.002315913,0.9888996,0.0004223968,0.004044107,0.000008291853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651536,0.00340202,0.02522345,0.0003182351,0.0001021295,0.00008085535,0.0006983915,0.0006163268,0.004405015],"genre_scores_gemma":[0.991169,0.0008194314,0.005030061,0.00007151495,0.00001550631,0.00003576172,0.0005244936,0.00007887965,0.002255332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002176357,"threshold_uncertainty_score":0.007280588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004846694863658422,"score_gpt":0.2009696147948471,"score_spread":0.1961229199311887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}