{"id":"W4404286134","doi":"10.1039/d4sc05459h","title":"Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling","year":2024,"lang":"en","type":"article","venue":"Chemical Science","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Government of Saskatchewan; Canadian Institutes of Health Research; National Science Foundation; Innosuisse - Schweizerische Agentur für Innovationsförderung; Michael Smith Health Research BC; European Federation of Pharmaceutical Industries and Associations; Cancer Research Society; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; McGill University; Novartis Foundation; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Peter und Traudl Engelhorn Stiftung; Canadian Light Source; Krebsliga Schweiz","keywords":"Covalent bond; Chemistry; PI3K/AKT/mTOR pathway; Pharmacology; Computational biology; Signal transduction; Biochemistry; Medicine; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055838,0.0004784534,0.000149107,0.000129306,0.0001685683,0.000189862,0.0003356092,0.0003276877,0.001377876],"category_scores_gemma":[0.0001892053,0.0001579556,0.0001989313,0.0001249295,0.0003187225,0.000282132,0.0002534561,0.0007974147,0.0004071671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003635112,"about_ca_system_score_gemma":0.0002950744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003044937,"about_ca_topic_score_gemma":0.0007966069,"domain_scores_codex":[0.9998639,0.00001885498,0.00000668206,0.00004001967,0.00003626533,0.00003431981],"domain_scores_gemma":[0.9999263,0.00001818855,0.00002729988,0.00001020379,0.000008443819,0.000009550624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005502372,0.00002008292,0.00005754103,0.00005093106,0.000005466218,0.00003364421,0.00001337626,0.0001750971,0.9958029,0.0005250879,0.00008418367,0.003176585],"study_design_scores_gemma":[0.000008762343,0.0001541383,0.0002043046,0.000002617473,0.000004193138,0.00007040817,0.000006110104,0.0003080163,0.9971944,0.00005519217,0.001988555,0.000003264063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9029028,0.003896167,0.07982758,0.0003835731,0.0001502343,0.0002314918,0.000500403,0.0004986285,0.01160917],"genre_scores_gemma":[0.9773306,0.001912491,0.01332872,0.000155731,0.00001886445,0.0001254233,0.0002752406,0.00004592684,0.006807021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001377876,"threshold_uncertainty_score":0.004609466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480380682711289,"score_gpt":0.2670623685113848,"score_spread":0.2522585616842719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}