{"id":"W4404286134","doi":"10.1039/d4sc05459h","title":"Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling","year":2024,"lang":"en","type":"article","venue":"Chemical Science","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Government of Saskatchewan; Canadian Institutes of Health Research; National Science Foundation; Innosuisse - Schweizerische Agentur für Innovationsförderung; Michael Smith Health Research BC; European Federation of Pharmaceutical Industries and Associations; Cancer Research Society; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; McGill University; Novartis Foundation; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Peter und Traudl Engelhorn Stiftung; Canadian Light Source; Krebsliga Schweiz","keywords":"Covalent bond; Chemistry; PI3K/AKT/mTOR pathway; Pharmacology; Computational biology; Signal transduction; Biochemistry; Medicine; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003785141,0.000176383,0.0001366604,0.00005543494,0.00009103005,0.000144356,0.0004456161,0.000108302,0.00003750873],"category_scores_gemma":[0.0001976681,0.0001559032,0.0001032781,0.0003314968,0.0005285764,0.0000119424,0.0003814131,0.0001365171,0.00002603815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010554,"about_ca_system_score_gemma":0.0001981252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005862896,"about_ca_topic_score_gemma":3.459909e-7,"domain_scores_codex":[0.9981568,0.00001161531,0.0001929204,0.0008485183,0.0003310155,0.0004591492],"domain_scores_gemma":[0.9992426,0.00002421196,0.00002515177,0.0002702116,0.00009011984,0.0003476934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002185418,0.00002015067,0.0001144961,0.0000425904,0.00001758613,0.00000455072,0.0000811825,0.00002557933,0.9915888,0.00005063003,0.001011937,0.007020602],"study_design_scores_gemma":[0.0001258096,0.00009451313,0.00003274993,0.00008533471,0.00001987892,0.00004819022,0.00003335834,0.0006694882,0.985594,0.00007399184,0.01298621,0.000236438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993477,0.004034443,0.0008240515,0.0006316586,0.0002787348,0.0001750796,0.00001151947,0.00004370683,0.0005237713],"genre_scores_gemma":[0.996255,0.00007320708,0.002628342,0.0004962878,0.0003176781,0.00003441204,0.000009351638,0.00001834708,0.0001673776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01197428,"threshold_uncertainty_score":0.6357548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480380682711289,"score_gpt":0.2670623685113848,"score_spread":0.2522585616842719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}