{"id":"W4404299214","doi":"10.21203/rs.3.rs-5363451/v1","title":"A Covalent Chemical Probe for Chikungunya nsP2 Cysteine Protease with Antialphaviral Activity and Proteome-wide Selectivity","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; University of Toronto","funders":"Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Ontario Genomics; Genome Canada; McGill University; Genentech; Bayer; Bristol-Myers Squibb","keywords":"Chikungunya; Covalent bond; Cysteine; Proteome; Chemistry; Selectivity; Protease; Cysteine protease; Biochemistry; Computational biology; Biophysics; Cell biology; Nanotechnology; Virology; Biology; Enzyme; Materials science; Virus; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004569775,0.0006158753,0.0001972872,0.0001548323,0.0003501829,0.0003343672,0.000515969,0.0007142621,0.003232998],"category_scores_gemma":[0.0003050283,0.0002642804,0.0003017897,0.0001722986,0.0003570542,0.0003377427,0.0003723665,0.0007671089,0.0006691036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004574423,"about_ca_system_score_gemma":0.0002562362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005021007,"about_ca_topic_score_gemma":0.001036746,"domain_scores_codex":[0.9997875,0.0000357879,0.000007264197,0.00006760185,0.00004839633,0.00005350496],"domain_scores_gemma":[0.9998553,0.00004508234,0.00002916929,0.00002012636,0.00002513207,0.00002517919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007004048,0.00001639012,0.00005387713,0.00004793595,0.000007614457,0.00003478151,0.0000127697,0.00004686635,0.9977591,0.0004090167,0.0001400826,0.001401505],"study_design_scores_gemma":[0.00001310182,0.0001272162,0.0003572139,0.000002367693,0.000008023141,0.0001018444,0.00000953417,0.0002567485,0.9965543,0.00004749628,0.002517938,0.000004291113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8985804,0.004147615,0.07148968,0.001173765,0.0003005686,0.0002649197,0.0008488812,0.0004086039,0.0227855],"genre_scores_gemma":[0.9597399,0.001809843,0.02191878,0.000657941,0.00007815885,0.0001538285,0.0008303522,0.00005988933,0.01475135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003232998,"threshold_uncertainty_score":0.01081544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03319703940959357,"score_gpt":0.3783957976814967,"score_spread":0.3451987582719031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}