{"id":"W4404302363","doi":"10.1161/circ.150.suppl_1.4136511","title":"Abstract 4136511: Targeting ATP Citrate Lyase: A Novel Therapeutic Strategy for Vascular Remodeling in Pulmonary Hypertension","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; University of Ottawa","funders":"","keywords":"Medicine; ATP citrate lyase; Pulmonary hypertension; Cardiology; Internal medicine; Pharmacology; Biochemistry; Enzyme; Citrate synthase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001884201,0.0006353917,0.0007145092,0.0004070693,0.0002166787,0.0005562673,0.0004319635,0.0008226536,0.006881976],"category_scores_gemma":[0.00007829165,0.0001409344,0.0004716316,0.0004350834,0.0002410293,0.0004146897,0.000326466,0.001363738,0.00167641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003031473,"about_ca_system_score_gemma":0.0004500705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003618868,"about_ca_topic_score_gemma":0.0008010429,"domain_scores_codex":[0.9999189,0.0000130836,0.000006280064,0.00001696237,0.00002047752,0.00002424428],"domain_scores_gemma":[0.9999678,0.000003589525,0.000007881302,0.000002378759,0.000006328741,0.00001205067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004469987,0.001679734,0.0006447171,0.002867304,0.0001649111,0.0007377475,0.00008895251,0.0005300621,0.8192362,0.002170127,0.01004402,0.1573661],"study_design_scores_gemma":[0.006406668,0.02780011,0.01788473,0.000773898,0.001110162,0.004524841,0.0002409707,0.003993718,0.6441778,0.002569797,0.2903856,0.0001318179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.6199596,0.3129897,0.01773323,0.008569273,0.003221297,0.00108911,0.00400663,0.001404385,0.03102675],"genre_scores_gemma":[0.8144987,0.131905,0.009633359,0.002772453,0.00101822,0.000644704,0.00452861,0.00008996129,0.0349089],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.006881976,"threshold_uncertainty_score":0.02302253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08785929461060774,"score_gpt":0.3255456193772963,"score_spread":0.2376863247666885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}