{"id":"W4404310616","doi":"10.1056/nejmoa2410819","title":"Tirzepatide for Obesity Treatment and Diabetes Prevention","year":2024,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Pharmacology and Obesity Treatment","field":"Medicine","cited_by":375,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eli Lilly and Company","keywords":"Obesity; Diabetes mellitus; Medicine; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00122511,0.0003501606,0.0006945592,0.000394356,0.0001438186,0.0004172841,0.0003020842,0.0004340012,0.004295705],"category_scores_gemma":[0.0009070573,0.0001561693,0.000975322,0.0003419929,0.0002457563,0.00022074,0.0002768761,0.0008199313,0.0003537391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003245745,"about_ca_system_score_gemma":0.0006496802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004003706,"about_ca_topic_score_gemma":0.001148676,"domain_scores_codex":[0.9994513,0.0003136046,0.00004257802,0.0000574403,0.000088599,0.00004638257],"domain_scores_gemma":[0.999529,0.0001533802,0.0002264643,0.00001905011,0.00002751865,0.00004460294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05512229,0.003417683,0.01158561,0.01145171,0.003128567,0.0005565014,0.0001242622,0.001076867,0.0293518,0.003127483,0.01078562,0.8702716],"study_design_scores_gemma":[0.2597084,0.1508407,0.2084517,0.009205858,0.01678886,0.01184574,0.0003322657,0.005751334,0.0305035,0.008202516,0.2980979,0.0002713093],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3553753,0.6116872,0.003009892,0.007309122,0.0009643405,0.0009232066,0.0007944555,0.0001346569,0.01980169],"genre_scores_gemma":[0.8234069,0.1637414,0.004648332,0.002811342,0.0007794535,0.0005365514,0.000465379,0.00001710876,0.003593577],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004295705,"threshold_uncertainty_score":0.01437056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03056387704478403,"score_gpt":0.3492625866933788,"score_spread":0.3186987096485948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}