{"id":"W4404319829","doi":"10.5267/j.ccl.2024.10.003","title":"Synthesis, characterization, and biological profiling of novel benzotriazole-thio linked derivatives as promising anti-inflammatory, analgesic, and antibacterial agents","year":2024,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Benzotriazole; Thio-; Analgesic; Anti-inflammatory; Antibacterial activity; Combinatorial chemistry; Antimicrobial; Pharmacology; Stereochemistry; Organic chemistry; Bacteria","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001994595,0.0003137425,0.0004247168,0.00003361083,0.0001039423,0.0001346327,0.0001629696,0.0002649742,0.0001941374],"category_scores_gemma":[0.0003653811,0.0002429307,0.00009616413,0.0001028887,0.000310347,0.0001796467,0.0001484008,0.000343283,0.000001671177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000327685,"about_ca_system_score_gemma":0.00003435085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001813873,"about_ca_topic_score_gemma":2.660924e-8,"domain_scores_codex":[0.9984609,0.00002974116,0.0004272867,0.0006268344,0.0001691214,0.0002861153],"domain_scores_gemma":[0.9991956,0.0002700324,0.0001994815,0.0001806542,0.00003893788,0.0001152633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005174752,0.000125789,0.02708931,0.001197436,0.00007866801,0.00000755249,0.00006593408,2.430719e-7,0.9601267,0.00001710974,0.000006008617,0.0112335],"study_design_scores_gemma":[0.0002759829,0.000003668427,0.0297375,0.0006901186,0.00004881293,0.00002186245,0.00003166116,0.0002927702,0.9680659,0.000008091216,0.000522041,0.0003016427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982512,0.000374507,0.0002767268,0.0005265081,0.0001463382,0.0001218998,0.0001448804,0.0001150117,0.00004293668],"genre_scores_gemma":[0.9987329,0.0004196659,0.0001646426,0.00001853814,0.0004669243,0.00002402692,0.0001499786,0.00002002845,0.000003286483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01093186,"threshold_uncertainty_score":0.9906425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837619774270599,"score_gpt":0.2725653399718344,"score_spread":0.2341891422291284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}