{"id":"W4404322781","doi":"10.1161/circ.150.suppl_1.4137414","title":"Abstract 4137414: Uncovering MLKL as a Novel Regulator of Endothelial Cells in the Splenic Niche to Repress Hematopoiesis During Atherosclerosis","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Heart Institute; Montreal Heart Institute; University of Ottawa","funders":"","keywords":"Regulator; Medicine; Haematopoiesis; Niche; Cell biology; Immunology; Stem cell; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638522,0.0003722892,0.0002393566,0.0002505486,0.0002060385,0.0004139878,0.0003401457,0.0003712104,0.002691306],"category_scores_gemma":[0.00007634817,0.0001297816,0.0002552102,0.0002048564,0.0002810099,0.0002812805,0.0002435457,0.0006748025,0.0009932333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004236682,"about_ca_system_score_gemma":0.0003449058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002261487,"about_ca_topic_score_gemma":0.0003547513,"domain_scores_codex":[0.999878,0.00001507583,0.000009804781,0.00003246367,0.00003749821,0.00002713354],"domain_scores_gemma":[0.9999213,0.000006217358,0.00002638176,0.000006173329,0.00001123131,0.00002868406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001775614,0.00001904051,0.0002945938,0.00007707414,0.000005743524,0.00007811329,0.000008905225,0.00005083414,0.997193,0.0001735426,0.0001322664,0.001789284],"study_design_scores_gemma":[0.0000753946,0.0004607802,0.0110415,0.00002597388,0.00005442202,0.0005961903,0.00007021139,0.00142613,0.9772722,0.0002304146,0.008737157,0.000009642421],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765188,0.006920943,0.008601518,0.001110475,0.0001479955,0.00009265282,0.001586278,0.000294609,0.004726812],"genre_scores_gemma":[0.9772438,0.00325499,0.006462997,0.0004998271,0.00006893087,0.00008941448,0.002031206,0.0000660934,0.01028271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002691306,"threshold_uncertainty_score":0.009003282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01563941963596414,"score_gpt":0.2332110225677369,"score_spread":0.2175716029317728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}