{"id":"W4404324405","doi":"10.1161/circ.150.suppl_1.4116714","title":"Abstract 4116714: Macrophage Colony Stimulating Factor as a Causal Metabolic Mediator of Cardiovascular Disease: An Observational and Mendelian Randomization Analysis","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"","keywords":"Mendelian randomization; Medicine; Observational study; Disease; Mediator; Risk factor; Internal medicine; Randomization; Randomized controlled trial; Gerontology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003387716,0.000134123,0.0003075591,0.0002546875,0.0001328994,0.0001347324,0.00007365199,0.00007040794,0.000298543],"category_scores_gemma":[0.0004005918,0.0001247001,0.0002391373,0.0007420295,0.00004842449,0.0004786879,0.00001920919,0.0001084897,0.000009984951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003285427,"about_ca_system_score_gemma":0.00006017655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007995153,"about_ca_topic_score_gemma":0.00000192731,"domain_scores_codex":[0.9984609,0.0001613049,0.0003261644,0.0004268016,0.0004790312,0.000145818],"domain_scores_gemma":[0.9992989,0.0002246726,0.00008870482,0.0002022987,0.00006947034,0.0001159868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001055017,0.00005115158,0.04539792,0.0001532057,0.0008578017,0.00003733514,0.001013214,0.4036421,0.5361676,0.002897468,0.00001145536,0.009665277],"study_design_scores_gemma":[0.0006983262,0.00001229787,0.2956637,0.00002460711,0.0008644222,0.000002188911,0.00002603036,0.6907455,0.01044478,0.0005198243,0.0008012298,0.0001970867],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902624,0.001204534,0.007813739,0.0001213562,0.0001404715,0.0002747139,0.00006998066,0.00008105006,0.00003172391],"genre_scores_gemma":[0.9994552,0.00005142014,0.0001104046,0.0001066651,0.000147172,0.00001132463,0.00008553868,0.0000247112,0.000007637486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5257228,"threshold_uncertainty_score":0.5085124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06466104525326037,"score_gpt":0.3032283916525418,"score_spread":0.2385673463992814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}