{"id":"W4404326103","doi":"10.1002/alz.14364","title":"Blood biomarkers in Down syndrome: Facilitating Alzheimer's disease detection and monitoring","year":2024,"lang":"en","type":"review","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Departament de Salut, Generalitat de Catalunya; Medical Research Council; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Vetenskapsrådet; European Commission; Familjen Erling-Perssons Stiftelse; Hjärnfonden; Fondation Jérôme Lejeune; University College London; HORIZON EUROPE Framework Programme; Alzheimer Society; Alzheimer's Society; Generalitat de Catalunya; National Institute on Aging; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Instituto de Salud Carlos III; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Alzheimer's Drug Discovery Foundation; Horizon 2020 Framework Programme; Foundation for the National Institutes of Health","keywords":"Disease; Medicine; Alzheimer's disease; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004765088,0.0008850967,0.0008918607,0.00225662,0.0004616989,0.002203064,0.0008270949,0.001294245,0.002414645],"category_scores_gemma":[0.01308913,0.0003413635,0.0006419674,0.001140604,0.0005089777,0.001702411,0.001390459,0.002056513,0.001001926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008252442,"about_ca_system_score_gemma":0.001391078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006606268,"about_ca_topic_score_gemma":0.005834506,"domain_scores_codex":[0.9977868,0.001017394,0.0002780406,0.0003395416,0.000452543,0.0001255476],"domain_scores_gemma":[0.9942467,0.002588106,0.0006717358,0.0002804009,0.001918045,0.0002949729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009821388,0.0002111174,0.1762745,0.002551465,0.0002872341,0.002903356,0.00143024,0.0009152035,0.02371107,0.009818199,0.02699134,0.7539241],"study_design_scores_gemma":[0.000228966,0.002058718,0.3139703,0.01374248,0.001702496,0.02157992,0.003753207,0.01113982,0.06977724,0.04003482,0.521606,0.0004061221],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2462646,0.4990216,0.1501506,0.04701201,0.004836945,0.0008162672,0.006235039,0.00236924,0.04329379],"genre_scores_gemma":[0.5923005,0.1912542,0.1920025,0.009963236,0.00257354,0.0006756033,0.002233746,0.0002217578,0.008775017],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006606268,"threshold_uncertainty_score":0.02520055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04849158524853479,"score_gpt":0.3567657035122787,"score_spread":0.3082741182637438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}