{"id":"W4404340851","doi":"10.1101/2024.11.13.24316906","title":"Peripheral immune profiles in individuals at genetic risk for amyotrophic lateral sclerosis and Alzheimer’s disease","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; Cure Alzheimer's Fund; Max-Planck-Institut für Bildungsforschung; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Rare Diseases Clinical Research Network","keywords":"Amyotrophic lateral sclerosis; Disease; Immune system; Medicine; Neuroscience; Cell; Immunology; Internal medicine; Psychology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003636738,0.0003449339,0.0003603095,0.0008459206,0.0003721584,0.0004146144,0.0001738762,0.0005114492,0.001990375],"category_scores_gemma":[0.001202115,0.0001706727,0.0002157187,0.0006340753,0.0001986125,0.0002713113,0.000267393,0.0004084204,0.0002341389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009503,"about_ca_system_score_gemma":0.00006583481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087026,"about_ca_topic_score_gemma":0.0009026853,"domain_scores_codex":[0.9998055,0.00005717455,0.00001966159,0.0000666094,0.00002424208,0.00002682223],"domain_scores_gemma":[0.9994891,0.0001231577,0.0001926422,0.00004384813,0.00005659593,0.00009464811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006050442,0.00005828253,0.9934657,0.00001374325,0.00006732914,0.0002277551,0.000108862,0.00004755122,0.003114367,0.00002634853,0.00009450423,0.002170532],"study_design_scores_gemma":[0.000008660416,0.0001401524,0.9989212,0.000003341095,0.00003005105,0.0003768839,0.0000706188,0.0001368282,0.0001736854,0.00005974816,0.00007556,0.000003251908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994889,0.0001273934,0.00007643552,0.00001472445,0.000003862749,0.000002262857,0.00009885379,0.000003573873,0.0001839727],"genre_scores_gemma":[0.9995452,0.00003384745,0.000110646,0.00002051617,0.000007457838,0.000004209473,0.0001065515,0.000001437944,0.0001700895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001990375,"threshold_uncertainty_score":0.006658494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04565364060846537,"score_gpt":0.3127904227626667,"score_spread":0.2671367821542013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}