{"id":"W4404347721","doi":"10.1101/2024.11.11.623066","title":"Aquaporin-4 and Caveolin-1 as Mediators of Fibrinogen-Driven Cerebrovascular Pathology in Cerebral Amyloid Angiopathy","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Intracerebral and Subarachnoid Hemorrhage Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"","keywords":"Cerebral amyloid angiopathy; Fibrinogen; Medicine; Pathology; Aquaporin 4; Amyloid (mycology); Caveolin 1; Angiopathy; Neuroscience; Internal medicine; Biology; Dementia; Endocrinology; Disease; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221396,0.0003212738,0.0003205753,0.0004352018,0.0002292152,0.0003270975,0.0003138593,0.0006939658,0.0005438746],"category_scores_gemma":[0.0001979717,0.0001809396,0.0003310264,0.0002064018,0.000497914,0.0006140288,0.0004234589,0.0006445776,0.00009215387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005237462,"about_ca_system_score_gemma":0.0002924058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009382344,"about_ca_topic_score_gemma":0.0006952732,"domain_scores_codex":[0.9998944,0.00001722729,0.000007724016,0.00002245422,0.00001911829,0.00003912611],"domain_scores_gemma":[0.9998622,0.00001173042,0.00005408727,0.000006396587,0.00001906629,0.00004645043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003476786,0.0001813034,0.01246485,0.0006404255,0.0001296362,0.003830059,0.0002435858,0.000345408,0.9613262,0.001993199,0.0006744968,0.01469406],"study_design_scores_gemma":[0.0005985606,0.003198603,0.4517217,0.0002003755,0.0008061038,0.01137698,0.001080762,0.006797043,0.4923906,0.01136802,0.0202931,0.0001682236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765736,0.01948331,0.001589752,0.0006861155,0.00007180982,0.00003491756,0.0001784569,0.00007755886,0.001304425],"genre_scores_gemma":[0.9933856,0.004161284,0.0008142447,0.0001819003,0.00003376042,0.00004748702,0.0001452858,0.000007225464,0.001223167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009382344,"threshold_uncertainty_score":0.003800035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002817957174161,"score_gpt":0.2407699211244323,"score_spread":0.2307417415526907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}