{"id":"W4404354036","doi":"10.1016/s1470-2045(24)00507-2","title":"Radiotherapy with cetuximab or durvalumab for locoregionally advanced head and neck cancer in patients with a contraindication to cisplatin (NRG-HN004): an open-label, multicentre, parallel-group, randomised, phase 2/3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"National Cancer Institute; NRG Oncology; National Center for Advancing Translational Sciences; AstraZeneca; U.S. Department of Veterans Affairs","keywords":"Cetuximab; Durvalumab; Medicine; Contraindication; Head and neck cancer; Cisplatin; Oncology; Radiation therapy; Internal medicine; Randomized controlled trial; Head and neck; Cancer; Surgery; Chemotherapy; Alternative medicine; Colorectal cancer; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004957942,0.0002421943,0.001098526,0.00008830782,0.0001279599,0.00004620077,0.0001956241,0.00008900278,0.00006201024],"category_scores_gemma":[0.00008190079,0.0001267751,0.00002176703,0.0002438443,0.0001498385,0.0001573985,0.00003449314,0.000207991,0.000001335976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003321721,"about_ca_system_score_gemma":0.0005556226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009925584,"about_ca_topic_score_gemma":0.004428791,"domain_scores_codex":[0.9983588,0.0001465966,0.0003534995,0.0004911175,0.000203414,0.0004465899],"domain_scores_gemma":[0.9988325,0.0005161338,0.0001238139,0.0002725257,0.0001023705,0.0001526301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8524884,0.001737349,0.001768288,0.0001374219,0.0002900067,0.00003270231,0.002544597,0.00003929777,0.0002458173,0.0002413248,0.000605783,0.139869],"study_design_scores_gemma":[0.9062642,0.04190276,0.009863148,0.0005758714,0.000188616,0.00001409935,0.0001635158,0.002019893,0.000009991452,0.00004012677,0.0387346,0.0002231532],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975014,0.001360149,0.000901784,0.01338904,0.0001863092,0.00876933,0.0001286953,0.00005653979,0.0001941574],"genre_scores_gemma":[0.9683735,0.001371276,0.01642971,0.005540533,0.000766976,0.006971742,0.0001240039,0.00008195853,0.0003402848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1396459,"threshold_uncertainty_score":0.5169739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06597821994464595,"score_gpt":0.4267055373765256,"score_spread":0.3607273174318796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}