{"id":"W4404359414","doi":"10.1161/circ.150.suppl_1.4143866","title":"Abstract 4143866: The Effect of S100A6 Gene Therapy on Cardiac Function in a Rat Model of Ischemic Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Ischemic cardiomyopathy; Cardiomyopathy; Cardiac function curve; Cardiology; Genetic enhancement; Internal medicine; Gene; Heart failure; Ejection fraction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00034331,0.0009904017,0.00100452,0.0007631275,0.0002465093,0.0002996446,0.0003763631,0.001105597,0.003336936],"category_scores_gemma":[0.0001347352,0.0002483203,0.000624267,0.0003433054,0.0005541822,0.0004584866,0.0002291815,0.00162789,0.0007428611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770514,"about_ca_system_score_gemma":0.0005076511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005459277,"about_ca_topic_score_gemma":0.0005472839,"domain_scores_codex":[0.99977,0.0000316049,0.00002553996,0.00004931043,0.00005072218,0.00007277622],"domain_scores_gemma":[0.9997841,0.00002135238,0.00005852279,0.00002295202,0.00002264249,0.0000904488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004635647,0.002470299,0.0001841816,0.0002029302,0.00002326579,0.0001568985,0.00003828932,0.0001672501,0.9842066,0.0001525547,0.000210823,0.00755128],"study_design_scores_gemma":[0.0007802074,0.03876518,0.003728939,0.00003912863,0.0001136712,0.0003799846,0.00007526748,0.001142137,0.9520168,0.0001096752,0.002827305,0.00002157301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930825,0.00249127,0.00154756,0.0003957922,0.0002235153,0.0001485599,0.0004563979,0.0001978588,0.001456523],"genre_scores_gemma":[0.9798921,0.003830815,0.003742533,0.000221239,0.00009201704,0.0004989386,0.001183995,0.00004728309,0.01049098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003336936,"threshold_uncertainty_score":0.01116318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111749649724126,"score_gpt":0.2375249339737634,"score_spread":0.2263499690013508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}